A Phase 1 Randomized, Placebo‐Controlled Trial With a Topical Inhibitor of Stearoyl‐Coenzyme A Desaturase 1 Under Occluded and Nonoccluded Conditions

Stearoyl‐coenzyme A desaturase 1 (SCD‐1) in sebaceous glands is a key enzyme in the synthesis of monounsaturated fatty acids essential for acne development. GSK1940029 gel, a novel SCD‐1 inhibitor, is being developed as a potential treatment for acne. To assess the irritation potential, pharmacokine...

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Detalles Bibliográficos
Autores principales: Brigandi, Richard A., Zhu, John, Murnane, Amy A., Reedy, Beth Ann, Shakib, Sepehr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590436/
https://www.ncbi.nlm.nih.gov/pubmed/30650256
http://dx.doi.org/10.1002/cpdd.644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590436/
https://www.ncbi.nlm.nih.gov/pubmed/30650256
http://dx.doi.org/10.1002/cpdd.644

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