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Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes

PURPOSE: We aimed to investigate the association between serum uric acid (SUA) levels and obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients with type 2 diabetes. METHODS: A cross-sectional study of 212 type 2 diabetes mellitus (T2DM) patients was conducted in Xiamen, China. All patients...

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Autores principales: Zheng, Caiyu, Song, Haiqu, Wang, Shunhua, Liu, Jing, Lin, Tingting, Du, Chunmin, Xie, Huan, Chen, Zhongyun, Zheng, Silan, Li, Zhibin, Li, Xuejun, Liu, Changqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590532/
https://www.ncbi.nlm.nih.gov/pubmed/31281547
http://dx.doi.org/10.1155/2019/4578327
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author Zheng, Caiyu
Song, Haiqu
Wang, Shunhua
Liu, Jing
Lin, Tingting
Du, Chunmin
Xie, Huan
Chen, Zhongyun
Zheng, Silan
Li, Zhibin
Li, Xuejun
Liu, Changqin
author_facet Zheng, Caiyu
Song, Haiqu
Wang, Shunhua
Liu, Jing
Lin, Tingting
Du, Chunmin
Xie, Huan
Chen, Zhongyun
Zheng, Silan
Li, Zhibin
Li, Xuejun
Liu, Changqin
author_sort Zheng, Caiyu
collection PubMed
description PURPOSE: We aimed to investigate the association between serum uric acid (SUA) levels and obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients with type 2 diabetes. METHODS: A cross-sectional study of 212 type 2 diabetes mellitus (T2DM) patients was conducted in Xiamen, China. All patients underwent polysomnography (PSG) recordings for OSAHS diagnosis. Patients were grouped according to the apnea-hypopnea index (AHI) as mild (5-14.9), moderate (15-29.9), and severe (≧30) OSAHS. Patients with AHI ≤ 4.9 served as the control group. Weight, body mass index (BMI), SUA, liver function, renal function, blood pressure, lipid profiles, and glycemic parameters were measured. RESULTS: A total of 158 patients (101 men and 57 women) with complete data were analyzed in this study. 127 patients were identified as OSAHS. Among the 127 patients with OSAHS, 56 (44.1%), 37 (29.1%), and 34 (26.8%) had mild, moderate, and severe OSAHS, respectively. Correlation analyses showed that the SUA level was significantly related to the apnea-hypopnea index (AHI) (r = 0.194, p = 0.016). The level of SUA was significantly higher among OSAHS patients compared to the control group (control group: 333.14 ± 80.52 μmol/L, mild group: 345.50 ± 90.27 μmol/L, moderate group: 363.59 ± 134.26 μmol/L, and severe group: 428.37 ± 123.58 μmol/L and p = 0.029). Multivariable logistic regression analyses showed that SUA was the independent risk factor for OSAHS (OR: 1.006, 95% CI: 1.001-1.011, p = 0.020). CONCLUSIONS: The SUA level is significantly associated with the severity of OSAHS and should be controlled when managing OSAHS.
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spelling pubmed-65905322019-07-07 Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes Zheng, Caiyu Song, Haiqu Wang, Shunhua Liu, Jing Lin, Tingting Du, Chunmin Xie, Huan Chen, Zhongyun Zheng, Silan Li, Zhibin Li, Xuejun Liu, Changqin Dis Markers Research Article PURPOSE: We aimed to investigate the association between serum uric acid (SUA) levels and obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients with type 2 diabetes. METHODS: A cross-sectional study of 212 type 2 diabetes mellitus (T2DM) patients was conducted in Xiamen, China. All patients underwent polysomnography (PSG) recordings for OSAHS diagnosis. Patients were grouped according to the apnea-hypopnea index (AHI) as mild (5-14.9), moderate (15-29.9), and severe (≧30) OSAHS. Patients with AHI ≤ 4.9 served as the control group. Weight, body mass index (BMI), SUA, liver function, renal function, blood pressure, lipid profiles, and glycemic parameters were measured. RESULTS: A total of 158 patients (101 men and 57 women) with complete data were analyzed in this study. 127 patients were identified as OSAHS. Among the 127 patients with OSAHS, 56 (44.1%), 37 (29.1%), and 34 (26.8%) had mild, moderate, and severe OSAHS, respectively. Correlation analyses showed that the SUA level was significantly related to the apnea-hypopnea index (AHI) (r = 0.194, p = 0.016). The level of SUA was significantly higher among OSAHS patients compared to the control group (control group: 333.14 ± 80.52 μmol/L, mild group: 345.50 ± 90.27 μmol/L, moderate group: 363.59 ± 134.26 μmol/L, and severe group: 428.37 ± 123.58 μmol/L and p = 0.029). Multivariable logistic regression analyses showed that SUA was the independent risk factor for OSAHS (OR: 1.006, 95% CI: 1.001-1.011, p = 0.020). CONCLUSIONS: The SUA level is significantly associated with the severity of OSAHS and should be controlled when managing OSAHS. Hindawi 2019-04-03 /pmc/articles/PMC6590532/ /pubmed/31281547 http://dx.doi.org/10.1155/2019/4578327 Text en Copyright © 2019 Caiyu Zheng et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zheng, Caiyu
Song, Haiqu
Wang, Shunhua
Liu, Jing
Lin, Tingting
Du, Chunmin
Xie, Huan
Chen, Zhongyun
Zheng, Silan
Li, Zhibin
Li, Xuejun
Liu, Changqin
Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes
title Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes
title_full Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes
title_fullStr Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes
title_full_unstemmed Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes
title_short Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes
title_sort serum uric acid is independently associated with risk of obstructive sleep apnea-hypopnea syndrome in chinese patients with type 2 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590532/
https://www.ncbi.nlm.nih.gov/pubmed/31281547
http://dx.doi.org/10.1155/2019/4578327
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