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Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr(−/−) Mice after Consumption of Guarana Soft Drinks

BACKGROUND: Excessive consumption of soft drinks (SD) has become a health problem worldwide due to its association with related cardiovascular diseases. We investigated the possible impacts associated with the consumption of Brazilian guarana (normal and zero) SD in dyslipidemic mice, thus mitigatin...

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Autores principales: Chisté, Layla Aparecida, Pereira, Beatriz Peters, Porto, Marcella Leite, de Oliveira, Jairo Pinto, de Assis, Arícia Leone Evangelista Monteiro, Nogueira, Breno Valentim, Meyrelles, Silvana Santos, de Andrade, Tadeu Uggere, Campos-Toimil, Manuel, Vasquez, Elisardo Corral, Campagnaro, Bianca Prandi, Pereira, Thiago Melo Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590538/
https://www.ncbi.nlm.nih.gov/pubmed/31281596
http://dx.doi.org/10.1155/2019/9042526
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author Chisté, Layla Aparecida
Pereira, Beatriz Peters
Porto, Marcella Leite
de Oliveira, Jairo Pinto
de Assis, Arícia Leone Evangelista Monteiro
Nogueira, Breno Valentim
Meyrelles, Silvana Santos
de Andrade, Tadeu Uggere
Campos-Toimil, Manuel
Vasquez, Elisardo Corral
Campagnaro, Bianca Prandi
Pereira, Thiago Melo Costa
author_facet Chisté, Layla Aparecida
Pereira, Beatriz Peters
Porto, Marcella Leite
de Oliveira, Jairo Pinto
de Assis, Arícia Leone Evangelista Monteiro
Nogueira, Breno Valentim
Meyrelles, Silvana Santos
de Andrade, Tadeu Uggere
Campos-Toimil, Manuel
Vasquez, Elisardo Corral
Campagnaro, Bianca Prandi
Pereira, Thiago Melo Costa
author_sort Chisté, Layla Aparecida
collection PubMed
description BACKGROUND: Excessive consumption of soft drinks (SD) has become a health problem worldwide due to its association with related cardiovascular diseases. We investigated the possible impacts associated with the consumption of Brazilian guarana (normal and zero) SD in dyslipidemic mice, thus mitigating potential clinical confounders such as poor-quality diet, lifestyle, body composition, and/or comorbidities. METHODS: Sixteen-month-old LDLr(−/−) mice were divided into the following groups: (1) control; (2) GSD: normal guarana SD; and (3) Z-GSD: zero guarana SD. All were fed ad libitum, and blood pressure was measured noninvasively. After 8 weeks, aorta, blood, liver, and stomach samples were collected for histological and biochemical analyses. RESULTS: Guarana soft drinks increased atherosclerosis (~60%) and were associated with hypercholesterolemia, hypertension, oxidative stress, DNA fragmentation, and apoptosis (~2-fold) of blood cells, besides presenting an increase in liver and gastric damage even in normoglycemia. Interestingly, Z-GSD did not cause the aforementioned changes, except in hemodynamic and renal parameters. CONCLUSIONS: Chronic administration of GSD is prooxidative, compromising the cardiovascular, gastric, and hepatic systems; the effects are due at least in part to free sugar consumption but not to guarana extract per se.
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spelling pubmed-65905382019-07-07 Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr(−/−) Mice after Consumption of Guarana Soft Drinks Chisté, Layla Aparecida Pereira, Beatriz Peters Porto, Marcella Leite de Oliveira, Jairo Pinto de Assis, Arícia Leone Evangelista Monteiro Nogueira, Breno Valentim Meyrelles, Silvana Santos de Andrade, Tadeu Uggere Campos-Toimil, Manuel Vasquez, Elisardo Corral Campagnaro, Bianca Prandi Pereira, Thiago Melo Costa Oxid Med Cell Longev Research Article BACKGROUND: Excessive consumption of soft drinks (SD) has become a health problem worldwide due to its association with related cardiovascular diseases. We investigated the possible impacts associated with the consumption of Brazilian guarana (normal and zero) SD in dyslipidemic mice, thus mitigating potential clinical confounders such as poor-quality diet, lifestyle, body composition, and/or comorbidities. METHODS: Sixteen-month-old LDLr(−/−) mice were divided into the following groups: (1) control; (2) GSD: normal guarana SD; and (3) Z-GSD: zero guarana SD. All were fed ad libitum, and blood pressure was measured noninvasively. After 8 weeks, aorta, blood, liver, and stomach samples were collected for histological and biochemical analyses. RESULTS: Guarana soft drinks increased atherosclerosis (~60%) and were associated with hypercholesterolemia, hypertension, oxidative stress, DNA fragmentation, and apoptosis (~2-fold) of blood cells, besides presenting an increase in liver and gastric damage even in normoglycemia. Interestingly, Z-GSD did not cause the aforementioned changes, except in hemodynamic and renal parameters. CONCLUSIONS: Chronic administration of GSD is prooxidative, compromising the cardiovascular, gastric, and hepatic systems; the effects are due at least in part to free sugar consumption but not to guarana extract per se. Hindawi 2019-06-10 /pmc/articles/PMC6590538/ /pubmed/31281596 http://dx.doi.org/10.1155/2019/9042526 Text en Copyright © 2019 Layla Aparecida Chisté et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chisté, Layla Aparecida
Pereira, Beatriz Peters
Porto, Marcella Leite
de Oliveira, Jairo Pinto
de Assis, Arícia Leone Evangelista Monteiro
Nogueira, Breno Valentim
Meyrelles, Silvana Santos
de Andrade, Tadeu Uggere
Campos-Toimil, Manuel
Vasquez, Elisardo Corral
Campagnaro, Bianca Prandi
Pereira, Thiago Melo Costa
Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr(−/−) Mice after Consumption of Guarana Soft Drinks
title Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr(−/−) Mice after Consumption of Guarana Soft Drinks
title_full Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr(−/−) Mice after Consumption of Guarana Soft Drinks
title_fullStr Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr(−/−) Mice after Consumption of Guarana Soft Drinks
title_full_unstemmed Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr(−/−) Mice after Consumption of Guarana Soft Drinks
title_short Worsening of Oxidative Stress, DNA Damage, and Atherosclerotic Lesions in Aged LDLr(−/−) Mice after Consumption of Guarana Soft Drinks
title_sort worsening of oxidative stress, dna damage, and atherosclerotic lesions in aged ldlr(−/−) mice after consumption of guarana soft drinks
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590538/
https://www.ncbi.nlm.nih.gov/pubmed/31281596
http://dx.doi.org/10.1155/2019/9042526
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