Cargando…

−254C>G SNP in the TRPC6 Gene Promoter Influences Its Expression via Interaction with the NF-κB Subunit RELA in Steroid-Resistant Nephrotic Syndrome Children

This study is aimed at exploring the mechanism by which the −254C>G single nucleotide polymorphism (SNP) on the transient receptor potential cation channel 6 (TRPC6) gene promoter could increase its activation in steroid-resistant nephrotic syndrome children of China. Plasmids containing the TRPC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuang, Xinyu, Zhou, Qian, Li, Zhuying, Hu, Yujie, Kang, Yulin, Huang, Wenyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590578/ https://www.ncbi.nlm.nih.gov/pubmed/31281825 http://dx.doi.org/10.1155/2019/2197837

Ejemplares similares

TRPC6 gene promoter polymorphisms in steroid resistant nephrotic syndrome children
por: Mahesh Kumar, Kempanahalli Basappa, et al.
Publicado: (2015)

Thr(435) phosphorylation regulates RelA (p65) NF-κB subunit transactivation
por: O'Shea, John M., et al.
Publicado: (2010)

Cyclophilin A (CypA) Interacts with NF-κB Subunit, p65/RelA, and Contributes to NF-κB Activation Signaling
por: Sun, Shan, et al.
Publicado: (2014)

RelA NF-κB subunit activation as a therapeutic target in diffuse large B-cell lymphoma
por: Zhang, Mingzhi, et al.
Publicado: (2016)

The NF-κB Subunit RelA/p65 Is Dispensable for Successful Liver Regeneration after Partial Hepatectomy in Mice
por: Ringelhan, Marc, et al.
Publicado: (2012)

NF-κB Repression by PIAS3 Mediated RelA SUMOylation
por: Liu, Yuangang, et al.
Publicado: (2012)

p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit
por: O'Hara, Andrew, et al.
Publicado: (2014)

Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination
por: Li, Haiying, et al.
Publicado: (2011)

The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation
por: Hochrainer, Karin, et al.
Publicado: (2015)

Distinct B subunits of PP2A regulate the NF‐κB signalling pathway through dephosphorylation of IKKβ, IκBα and RelA
por: Tsuchiya, Yoshihiro, et al.
Publicado: (2017)

IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer
por: Tsui, Rachel, et al.
Publicado: (2015)

Requirement for the NF-κB Family Member RelA in the Development of Secondary Lymphoid Organs
por: Alcamo, Elizabeth, et al.
Publicado: (2002)

PTPIP51—A New RelA-tionship with the NFκB Signaling Pathway
por: Brobeil, Alexander, et al.
Publicado: (2015)

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability
por: Ronin, Emilie, et al.
Publicado: (2019)

NFκB (RelA) mediates transactivation of hnRNPD in oral cancer cells
por: Kumar, Vikas, et al.
Publicado: (2022)

Hyperglycemic Conditions Promote Rac1-Mediated Serine536 Phosphorylation of p65 Subunit of NFκB (RelA) in Pancreatic Beta Cells
por: Kowluru, Anjaneyulu, et al.
Publicado: (2022)

C11orf95-RELA fusions drive oncogenic NF-κB signaling in ependymoma
por: Parker, Matthew, et al.
Publicado: (2014)

NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells
por: Han, Dongfeng, et al.
Publicado: (2015)

Differential expression of NF-κB heterodimer RelA/p50 in human urothelial carcinoma
por: Durairajan, Sankari, et al.
Publicado: (2018)

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage
por: Campbell, Amy E., et al.
Publicado: (2021)

NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer
por: Koerner, Lioba, et al.
Publicado: (2023)

TWIST1 associates with NF-κB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production
por: Li, Shan, et al.
Publicado: (2012)

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury
por: Lanzillotta, A, et al.
Publicado: (2010)

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury
Publicado: (2010)

Methylation of the RELA Gene is Associated with Expression of NF-κB1 in Response to TNF-α in Breast Cancer
por: Jeong, Young Ju, et al.
Publicado: (2019)

NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancer
por: Geismann, Claudia, et al.
Publicado: (2023)

Celecoxib Suppresses NF-κB p65 (RelA) and TNFα Expression Signaling in Glioblastoma
por: Ahsan, Hina, et al.
Publicado: (2023)

Enterovirus 71 2C Protein Inhibits NF-κB Activation by Binding to RelA(p65)
por: Du, Haiwei, et al.
Publicado: (2015)

NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
por: Kabacaoglu, Derya, et al.
Publicado: (2019)

An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF‐induced necroptosis decisions
por: Oliver Metzig, Marie, et al.
Publicado: (2020)

Extracellular ATP Activates Transcription Factor NF-κB through the P2Z Purinoreceptor by Selectively Targeting NF-κB p65 (RelA)
por: Ferrari, Davide, et al.
Publicado: (1997)

The Regulation of NF-κB Subunits by Phosphorylation
por: Christian, Frank, et al.
Publicado: (2016)

Inhibition of Diacylglycerol–Sensitive TRPC Channels by Synthetic and Natural Steroids
por: Miehe, Susanne, et al.
Publicado: (2012)

SNP-SNP interaction analysis of NF-κB signaling pathway on breast cancer survival
por: Jamshidi, Maral, et al.
Publicado: (2015)

Activation of TRPC6 by AngⅡ Induces Podocyte Injury and Participates in Proteinuria of Nephrotic Syndrome
por: Feng, Ye, et al.
Publicado: (2022)

Prediction of steroid resistance and steroid dependence in nephrotic syndrome children
por: Zaorska, Katarzyna, et al.
Publicado: (2021)

SETD6 lysine methylation of RelA couples GLP activity at chromatin to tonic repression of NF-κB signaling
por: Levy, Dan, et al.
Publicado: (2010)

Forkhead Transcription Factor FOXP3 Upregulates CD25 Expression through Cooperation with RelA/NF-κB
por: Camperio, Cristina, et al.
Publicado: (2012)

AGE-RAGE signal generates a specific NF-κB RelA “barcode” that directs collagen I expression
por: Peng, Yunqian, et al.
Publicado: (2016)

microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NF-κB
por: Giles, Keith M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4qhhmkvei36rl91fj3ils09j3o