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Assessment of herd effects among women and heterosexual men after girls‐only HPV16/18 vaccination in the Netherlands: A repeated cross‐sectional study

Data on the impact of human papillomavirus (HPV) vaccination on the population HPV prevalence are largely obtained from women. We assessed the impact of the girls‐only HPV16/18 vaccination program in the Netherlands that started in 2009, on trends in HPV prevalence among women and heterosexual men,...

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Autores principales: Woestenberg, Petra J, Bogaards, Johannes A, King, Audrey J, Leussink, Suzan, van der Sande, Marianne AB, Hoebe, Christian JPA, van Benthem, Birgit HB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590597/
https://www.ncbi.nlm.nih.gov/pubmed/30426502
http://dx.doi.org/10.1002/ijc.31989
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author Woestenberg, Petra J
Bogaards, Johannes A
King, Audrey J
Leussink, Suzan
van der Sande, Marianne AB
Hoebe, Christian JPA
van Benthem, Birgit HB
author_facet Woestenberg, Petra J
Bogaards, Johannes A
King, Audrey J
Leussink, Suzan
van der Sande, Marianne AB
Hoebe, Christian JPA
van Benthem, Birgit HB
author_sort Woestenberg, Petra J
collection PubMed
description Data on the impact of human papillomavirus (HPV) vaccination on the population HPV prevalence are largely obtained from women. We assessed the impact of the girls‐only HPV16/18 vaccination program in the Netherlands that started in 2009, on trends in HPV prevalence among women and heterosexual men, using data from the PASSYON study. In this cross‐sectional study, the HPV prevalence among 16‐ to 24‐year‐old visitors to sexually transmitted infection clinics was assessed in 2009, 2011, 2013, and 2015. We compared the genital postvaccination HPV prevalence with the prevaccination prevalence (2009) using Poisson GEE models. In total, we included 4,996 women and 1,901 heterosexual men. The percentage of women who reported to be vaccinated increased from 2.3% in 2009 to 37% in 2015. Among all women, the HPV16/18 prevalence decreased from 23% prevaccination to 15% in 2015 (adjusted prevalence ratio [aPR] 0.62, p (trend) < 0.01). Among heterosexual men, the HPV16/18 prevalence decreased from 17% prevaccination to 11% in 2015 (aPR 0.52, p (trend) < 0.01). Of the heterosexual men with a steady partner, HPV16/18 prevalence was lower among those whose steady partner had been vaccine‐eligible in the national immunization program (aPR 0.13). Among unvaccinated women, the HPV16/18 prevalence in 2015 was not different from prevaccination. The decreasing HPV16/18 prevalence among heterosexual men and the reduced HPV16/18 prevalence among heterosexual men with a vaccine‐eligible steady partner strongly suggests herd protection from girls‐only vaccination. Absence of notable herd effects among unvaccinated women 6 years postvaccination may be due to the moderate vaccine uptake among girls in the Netherlands.
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spelling pubmed-65905972019-07-08 Assessment of herd effects among women and heterosexual men after girls‐only HPV16/18 vaccination in the Netherlands: A repeated cross‐sectional study Woestenberg, Petra J Bogaards, Johannes A King, Audrey J Leussink, Suzan van der Sande, Marianne AB Hoebe, Christian JPA van Benthem, Birgit HB Int J Cancer Infectious Causes of Cancer Data on the impact of human papillomavirus (HPV) vaccination on the population HPV prevalence are largely obtained from women. We assessed the impact of the girls‐only HPV16/18 vaccination program in the Netherlands that started in 2009, on trends in HPV prevalence among women and heterosexual men, using data from the PASSYON study. In this cross‐sectional study, the HPV prevalence among 16‐ to 24‐year‐old visitors to sexually transmitted infection clinics was assessed in 2009, 2011, 2013, and 2015. We compared the genital postvaccination HPV prevalence with the prevaccination prevalence (2009) using Poisson GEE models. In total, we included 4,996 women and 1,901 heterosexual men. The percentage of women who reported to be vaccinated increased from 2.3% in 2009 to 37% in 2015. Among all women, the HPV16/18 prevalence decreased from 23% prevaccination to 15% in 2015 (adjusted prevalence ratio [aPR] 0.62, p (trend) < 0.01). Among heterosexual men, the HPV16/18 prevalence decreased from 17% prevaccination to 11% in 2015 (aPR 0.52, p (trend) < 0.01). Of the heterosexual men with a steady partner, HPV16/18 prevalence was lower among those whose steady partner had been vaccine‐eligible in the national immunization program (aPR 0.13). Among unvaccinated women, the HPV16/18 prevalence in 2015 was not different from prevaccination. The decreasing HPV16/18 prevalence among heterosexual men and the reduced HPV16/18 prevalence among heterosexual men with a vaccine‐eligible steady partner strongly suggests herd protection from girls‐only vaccination. Absence of notable herd effects among unvaccinated women 6 years postvaccination may be due to the moderate vaccine uptake among girls in the Netherlands. John Wiley & Sons, Inc. 2018-12-21 2019-06-01 /pmc/articles/PMC6590597/ /pubmed/30426502 http://dx.doi.org/10.1002/ijc.31989 Text en © 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Infectious Causes of Cancer
Woestenberg, Petra J
Bogaards, Johannes A
King, Audrey J
Leussink, Suzan
van der Sande, Marianne AB
Hoebe, Christian JPA
van Benthem, Birgit HB
Assessment of herd effects among women and heterosexual men after girls‐only HPV16/18 vaccination in the Netherlands: A repeated cross‐sectional study
title Assessment of herd effects among women and heterosexual men after girls‐only HPV16/18 vaccination in the Netherlands: A repeated cross‐sectional study
title_full Assessment of herd effects among women and heterosexual men after girls‐only HPV16/18 vaccination in the Netherlands: A repeated cross‐sectional study
title_fullStr Assessment of herd effects among women and heterosexual men after girls‐only HPV16/18 vaccination in the Netherlands: A repeated cross‐sectional study
title_full_unstemmed Assessment of herd effects among women and heterosexual men after girls‐only HPV16/18 vaccination in the Netherlands: A repeated cross‐sectional study
title_short Assessment of herd effects among women and heterosexual men after girls‐only HPV16/18 vaccination in the Netherlands: A repeated cross‐sectional study
title_sort assessment of herd effects among women and heterosexual men after girls‐only hpv16/18 vaccination in the netherlands: a repeated cross‐sectional study
topic Infectious Causes of Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590597/
https://www.ncbi.nlm.nih.gov/pubmed/30426502
http://dx.doi.org/10.1002/ijc.31989
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