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Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma
Objectives: To prove that our novel ethanolamine derivative (FDES) can normalize overall movement and exploratory activity of rats with traumatic brain injury (TBI) owing to its peculiar properties. Materials and methods: TBI was modeled using controlled cortical impact injury (CCI) model method. Th...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590625/ https://www.ncbi.nlm.nih.gov/pubmed/31354367 http://dx.doi.org/10.2147/JEP.S199464 |
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author | Sysoev, Yuriy Igorevich Uzuegbunam, Bright Chukwunwike Okovityi, Sergey Vladimirovich |
author_facet | Sysoev, Yuriy Igorevich Uzuegbunam, Bright Chukwunwike Okovityi, Sergey Vladimirovich |
author_sort | Sysoev, Yuriy Igorevich |
collection | PubMed |
description | Objectives: To prove that our novel ethanolamine derivative (FDES) can normalize overall movement and exploratory activity of rats with traumatic brain injury (TBI) owing to its peculiar properties. Materials and methods: TBI was modeled using controlled cortical impact injury (CCI) model method. The resulting neurological deficit, efficacy of the novel agent and other reference agents used were assayed in tests which evaluated overall movements and exploratory behavior of the rats. Finally, scopolamine in equimolar dose was used to estimate the role of cholinergic system in the efficacy of our agent. The tests included: limb-placing, open field, elevated plus maze, cylinder, and beam walking tests. Results: Intraperitoneal administration of FDES at a dose of 10 mg/kg led to improvement of fore- and hind-limb functions of rats with traumatic brain injury as was shown in “Limb placing”, “Open field” “Cylinder” and “Beam walking” tests. The new agent had no effects on traumatized rats behavior in the “Elevated Plus Maze” test. Simultaneous co-administration of scopolamine with FDES reduced the beneficial effects of the latter in rats with trauma. Conclusion: The neuroprotective effects of new agent were manifested in the reduction of motor deficiencies, and exploratory activity in the CCI model rats. In comparison with choline alfoscerate and citicoline, FDES showed more beneficial effects as were observed in most of the tests, and did not negatively influence the traumatized rats psychologically. Notably, it is possible that the neuroprotective influence of the new agent is mediated by its actions on the cholinergic system. |
format | Online Article Text |
id | pubmed-6590625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-65906252019-07-26 Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma Sysoev, Yuriy Igorevich Uzuegbunam, Bright Chukwunwike Okovityi, Sergey Vladimirovich J Exp Pharmacol Original Research Objectives: To prove that our novel ethanolamine derivative (FDES) can normalize overall movement and exploratory activity of rats with traumatic brain injury (TBI) owing to its peculiar properties. Materials and methods: TBI was modeled using controlled cortical impact injury (CCI) model method. The resulting neurological deficit, efficacy of the novel agent and other reference agents used were assayed in tests which evaluated overall movements and exploratory behavior of the rats. Finally, scopolamine in equimolar dose was used to estimate the role of cholinergic system in the efficacy of our agent. The tests included: limb-placing, open field, elevated plus maze, cylinder, and beam walking tests. Results: Intraperitoneal administration of FDES at a dose of 10 mg/kg led to improvement of fore- and hind-limb functions of rats with traumatic brain injury as was shown in “Limb placing”, “Open field” “Cylinder” and “Beam walking” tests. The new agent had no effects on traumatized rats behavior in the “Elevated Plus Maze” test. Simultaneous co-administration of scopolamine with FDES reduced the beneficial effects of the latter in rats with trauma. Conclusion: The neuroprotective effects of new agent were manifested in the reduction of motor deficiencies, and exploratory activity in the CCI model rats. In comparison with choline alfoscerate and citicoline, FDES showed more beneficial effects as were observed in most of the tests, and did not negatively influence the traumatized rats psychologically. Notably, it is possible that the neuroprotective influence of the new agent is mediated by its actions on the cholinergic system. Dove 2019-06-19 /pmc/articles/PMC6590625/ /pubmed/31354367 http://dx.doi.org/10.2147/JEP.S199464 Text en © 2019 Sysoev et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Sysoev, Yuriy Igorevich Uzuegbunam, Bright Chukwunwike Okovityi, Sergey Vladimirovich Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma |
title | Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma |
title_full | Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma |
title_fullStr | Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma |
title_full_unstemmed | Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma |
title_short | Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma |
title_sort | attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590625/ https://www.ncbi.nlm.nih.gov/pubmed/31354367 http://dx.doi.org/10.2147/JEP.S199464 |
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