Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of C. difficile toxin B

Clostridium difficile infection (CDI) is a major nosocomial disease associated with significant morbidity and mortality. The pathology of CDI stems primarily from the 2 C. difficile–secreted exotoxins—toxin A (TcdA) and toxin B (TcdB)—that disrupt the tight junctions between epithelial cells leading...

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Detalles Bibliográficos
Autores principales: Simeon, Rudo, Jiang, Mengqiu, Chamoun-Emanuelli, Ana M., Yu, Hua, Zhang, Yongrong, Meng, Ran, Peng, Zeyu, Jakana, Joanita, Zhang, Junjie, Feng, Hanping, Chen, Zhilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590788/
https://www.ncbi.nlm.nih.gov/pubmed/31233493
http://dx.doi.org/10.1371/journal.pbio.3000311

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