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Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice

Interruption of bile acid recirculation through inhibition of the apical sodium-dependent bile acid transporter (ASBT) is a promising strategy to alleviate hepatic cholesterol accumulation in non-alcoholic steatohepatitis (NASH), and improve the metabolic aspects of the disease. Potential disease-at...

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Detalles Bibliográficos
Autores principales:	Salic, Kanita, Kleemann, Robert, Wilkins-Port, Cynthia, McNulty, John, Verschuren, Lars, Palmer, Melissa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590809/ https://www.ncbi.nlm.nih.gov/pubmed/31233523 http://dx.doi.org/10.1371/journal.pone.0218459

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