Viral engagement with host receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid

Enterovirus A71 (EV-A71) is a non-polio neurotropic enterovirus with pandemic potential. There are no antiviral agents approved to prevent or treat EV-A71 infections. We here report on the molecular mechanism by which a novel class of tryptophan dendrimers inhibits (at low nanomolar to high picomola...

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Detalles Bibliográficos
Autores principales: Sun, Liang, Lee, Hyunwook, Thibaut, Hendrik Jan, Lanko, Kristina, Rivero-Buceta, Eva, Bator, Carol, Martinez-Gualda, Belen, Dallmeier, Kai, Delang, Leen, Leyssen, Pieter, Gago, Federico, San-Félix, Ana, Hafenstein, Susan, Mirabelli, Carmen, Neyts, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590834/
https://www.ncbi.nlm.nih.gov/pubmed/31071193
http://dx.doi.org/10.1371/journal.ppat.1007760

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