Heterozygous IDH1(R132H/WT) created by “single base editing” inhibits human astroglial cell growth by downregulating YAP

Mutations in the isocitrate dehydrogenase 1 (IDH1) gene have been identified in a number of cancer types, including brain cancer. The Cancer Genome Atlas project has revealed that IDH1 mutations occur in 70–80% of grade II and grade III gliomas. Until recently, most of the functional studies of IDH1...

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Detalles Bibliográficos
Autores principales: Wei, Shuang, Wang, Jie, Oyinlade, Olutobi, Ma, Ding, Wang, Shuyan, Kratz, Lisa, Lal, Bachchu, Xu, Qingfu, Liu, Senquan, Shah, Sagar R., Zhang, Hao, Li, Yunqing, Quiñones-Hinojosa, Alfredo, Zhu, Heng, Huang, Zhi-yong, Cheng, Linzhao, Qian, Jiang, Xia, Shuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590918/
https://www.ncbi.nlm.nih.gov/pubmed/29849122
http://dx.doi.org/10.1038/s41388-018-0334-9

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