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Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network

In oscillatory systems, neuronal activity phase is often independent of network frequency. Such phase maintenance requires adjustment of synaptic input with network frequency, a relationship that we explored using the crab, Cancer borealis, pyloric network. The burst phase of pyloric neurons is rela...

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Autores principales: Martinez, Diana, Anwar, Haroon, Bose, Amitabha, Bucher, Dirk M, Nadim, Farzan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590986/
https://www.ncbi.nlm.nih.gov/pubmed/31180323
http://dx.doi.org/10.7554/eLife.46911
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author Martinez, Diana
Anwar, Haroon
Bose, Amitabha
Bucher, Dirk M
Nadim, Farzan
author_facet Martinez, Diana
Anwar, Haroon
Bose, Amitabha
Bucher, Dirk M
Nadim, Farzan
author_sort Martinez, Diana
collection PubMed
description In oscillatory systems, neuronal activity phase is often independent of network frequency. Such phase maintenance requires adjustment of synaptic input with network frequency, a relationship that we explored using the crab, Cancer borealis, pyloric network. The burst phase of pyloric neurons is relatively constant despite a > two fold variation in network frequency. We used noise input to characterize how input shape influences burst delay of a pyloric neuron, and then used dynamic clamp to examine how burst phase depends on the period, amplitude, duration, and shape of rhythmic synaptic input. Phase constancy across a range of periods required a proportional increase of synaptic duration with period. However, phase maintenance was also promoted by an increase of amplitude and peak phase of synaptic input with period. Mathematical analysis shows how short-term synaptic plasticity can coordinately change amplitude and peak phase to maximize the range of periods over which phase constancy is achieved.
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spelling pubmed-65909862019-06-26 Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network Martinez, Diana Anwar, Haroon Bose, Amitabha Bucher, Dirk M Nadim, Farzan eLife Neuroscience In oscillatory systems, neuronal activity phase is often independent of network frequency. Such phase maintenance requires adjustment of synaptic input with network frequency, a relationship that we explored using the crab, Cancer borealis, pyloric network. The burst phase of pyloric neurons is relatively constant despite a > two fold variation in network frequency. We used noise input to characterize how input shape influences burst delay of a pyloric neuron, and then used dynamic clamp to examine how burst phase depends on the period, amplitude, duration, and shape of rhythmic synaptic input. Phase constancy across a range of periods required a proportional increase of synaptic duration with period. However, phase maintenance was also promoted by an increase of amplitude and peak phase of synaptic input with period. Mathematical analysis shows how short-term synaptic plasticity can coordinately change amplitude and peak phase to maximize the range of periods over which phase constancy is achieved. eLife Sciences Publications, Ltd 2019-06-10 /pmc/articles/PMC6590986/ /pubmed/31180323 http://dx.doi.org/10.7554/eLife.46911 Text en © 2019, Martinez et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Martinez, Diana
Anwar, Haroon
Bose, Amitabha
Bucher, Dirk M
Nadim, Farzan
Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network
title Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network
title_full Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network
title_fullStr Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network
title_full_unstemmed Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network
title_short Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network
title_sort short-term synaptic dynamics control the activity phase of neurons in an oscillatory network
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590986/
https://www.ncbi.nlm.nih.gov/pubmed/31180323
http://dx.doi.org/10.7554/eLife.46911
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