METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation

7-methylguanosine (m7G) is present at mRNA caps and at defined internal positions within tRNAs and rRNAs. However, its detection within low-abundance mRNAs and microRNAs (miRNAs) has been hampered by a lack of sensitive detection strategies. Here, we adapt a chemical reactivity assay to detect inter...

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Detalles Bibliográficos
Autores principales: Pandolfini, Luca, Barbieri, Isaia, Bannister, Andrew J., Hendrick, Alan, Andrews, Byron, Webster, Natalie, Murat, Pierre, Mach, Pia, Brandi, Rossella, Robson, Samuel C., Migliori, Valentina, Alendar, Andrej, d’Onofrio, Mara, Balasubramanian, Shankar, Kouzarides, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591002/
https://www.ncbi.nlm.nih.gov/pubmed/31031083
http://dx.doi.org/10.1016/j.molcel.2019.03.040

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