Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

Broadly neutralizing antibodies (bNAbs) against HIV-1 envelope (Env) inform vaccine design and are potential therapeutic agents. We identified SF12 and related bNAbs with up to 62% neutralization breadth from an HIV-infected donor. SF12 recognized a glycan-dominated epitope on Env’s silent face and...

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Detalles Bibliográficos
Autores principales: Schoofs, Till, Barnes, Christopher O., Suh-Toma, Nina, Golijanin, Jovana, Schommers, Philipp, Gruell, Henning, West, Anthony P., Bach, Franziska, Lee, Yu Erica, Nogueira, Lilian, Georgiev, Ivelin S., Bailer, Robert T., Czartoski, Julie, Mascola, John R., Seaman, Michael S., McElrath, M. Juliana, Doria-Rose, Nicole A., Klein, Florian, Nussenzweig, Michel C., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591006/
https://www.ncbi.nlm.nih.gov/pubmed/31126879
http://dx.doi.org/10.1016/j.immuni.2019.04.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591006/
https://www.ncbi.nlm.nih.gov/pubmed/31126879
http://dx.doi.org/10.1016/j.immuni.2019.04.014

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