Cargando…

NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells

The mechanistic basis of gliogenesis, which occurs late in human development, is poorly understood. Here we identify nuclear factor IA (NFIA) as a molecular switch for inducing human glial competency. Transient expression of NFIA is sufficient to trigger glial competency of human pluripotent stem ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tchieu, Jason, Calder, Elizabeth L., Guttikonda, Sudha R., Gutzwiller, Eveline M., Aromolaran, Kelly A., Steinbeck, Julius A., Goldstein, Peter A., Studer, Lorenz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591152/ https://www.ncbi.nlm.nih.gov/pubmed/30804533 http://dx.doi.org/10.1038/s41587-019-0035-0

Ejemplares similares

Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity
por: Kong, Shuo, et al.
Publicado: (2023)

Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer’s disease
por: Guttikonda, Sudha R., et al.
Publicado: (2021)

PM492. Schizophrenia patient-derived induced pluripotent stem cells exhibit changes in neurogenic and gliogenic competences
por: Toyoshima, Manabu, et al.
Publicado: (2016)

The (Real) Neurogenic/Gliogenic Potential of the Postnatal and Adult Brain Parenchyma
por: Bonfanti, Luca
Publicado: (2013)

Neurogenic to Gliogenic Fate Transition Perturbed by Loss of HMGB2
por: Bronstein, Robert, et al.
Publicado: (2017)

The HOPX and BLBP landscape and gliogenic regions in developing human brain
por: Holst, Camilla Bjørnbak, et al.
Publicado: (2023)

NFIA haploinsufficiency: case series and literature review
por: Dini, Gianluca, et al.
Publicado: (2023)

SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia
por: Takouda, Jun, et al.
Publicado: (2021)

MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells
por: Tsuyama, Jun, et al.
Publicado: (2015)

Gliogenic Potential of Single Pallial Radial Glial Cells in Lower Cortical Layers
por: Ojalvo-Sanz, Ana Cristina, et al.
Publicado: (2021)

Combined allelic dosage of Nfia and Nfib regulates cortical development
por: Bunt, Jens, et al.
Publicado: (2017)

A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury
por: Kamata, Yasuhiro, et al.
Publicado: (2020)

Truncating mutation in NFIA causes brain malformation and urinary tract defects
por: Negishi, Yutaka, et al.
Publicado: (2015)

Phenotypic Spectrum of NFIA Haploinsufficiency: Two Additional Cases and Review of the Literature
por: Bertini, Veronica, et al.
Publicado: (2022)

Chondrogenic and Gliogenic Subpopulations of Neural Crest Play Distinct Roles during the Assembly of Epibranchial Ganglia
por: Culbertson, Maya D., et al.
Publicado: (2011)

Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain
por: Lee, Han-Chung, et al.
Publicado: (2016)

NFIA Haploinsufficiency Is Associated with a CNS Malformation Syndrome and Urinary Tract Defects
por: Lu, Weining, et al.
Publicado: (2007)

Targeted Sequencing in Chromosome 17q Linkage Region Identifies Familial Glioma Candidates in the Gliogene Consortium
por: Jalali, Ali, et al.
Publicado: (2015)

PAX6 does not regulate Nfia and Nfib expression during neocortical development
por: Bunt, Jens, et al.
Publicado: (2015)

Prognostic significance of NFIA and NFIB in esophageal squamous carcinoma and esophagogastric junction adenocarcinoma
por: Yang, Bo, et al.
Publicado: (2018)

Identification and validation of NFIA as a novel prognostic marker in renal cell carcinoma
por: de Alwis, Roger, et al.
Publicado: (2023)

Genetic lineage tracing defines distinct neurogenic and gliogenic stages of ventral telencephalic radial glial development
por: Anthony, Todd E, et al.
Publicado: (2008)

Nfia deletion in myeloid cells blocks expansion of myeloid-derived suppressor cells during sepsis
por: Dai, Jun, et al.
Publicado: (2017)

miR-181d-5p Protects against Retinal Ganglion Cell Death after Blunt Ocular Injury by Regulating NFIA-Medicated Astrocyte Development
por: Li, Jinghua, et al.
Publicado: (2022)

DERIVING HUMAN ENS LINEAGES FOR CELL THERAPY AND DRUG DISCOVERY IN HIRSCHSPRUNG'S DISEASE
por: Fattahi, Faranak, et al.
Publicado: (2016)

NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes
por: Hiraike, Yuta, et al.
Publicado: (2022)

Roles of ES Cell-Derived Gliogenic Neural Stem/Progenitor Cells in Functional Recovery after Spinal Cord Injury
por: Kumagai, Gentaro, et al.
Publicado: (2009)

A novel feature of the ancient organ: A possible involvement of the subcommissural organ in neurogenic/gliogenic potential in the adult brain
por: Inada, Hitoshi, et al.
Publicado: (2023)

Tracing the origins of glioblastoma by investigating the role of gliogenic and related neurogenic genes/signaling pathways in GBM development: a systematic review
por: Shafi, Ovais, et al.
Publicado: (2022)

Mutual Antagonism Between Sox10 and NFIA Regulates Diversification of Glial Lineages and Glioma Sub-Types
por: Glasgow, Stacey, et al.
Publicado: (2014)

Cortical Astrocyte Progenitors and Astrocytes from Human Pluripotent Stem Cells
por: Battistella, Ingrid, et al.
Publicado: (2023)

MiRNA-671-5p Promotes prostate cancer development and metastasis by targeting NFIA/CRYAB axis
por: Zhu, Zhiguo, et al.
Publicado: (2020)

SPECIFICATION OF POSITIONAL IDENTITY IN FOREBRAIN ORGANOIDS
por: Cederquist, Gustav Y., et al.
Publicado: (2019)

Single‐cell study of neural stem cells derived from human iPSCs reveals distinct progenitor populations with neurogenic and gliogenic potential
por: Lam, Matti, et al.
Publicado: (2019)

Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy: Cause and effect?
por: Aromolaran, Kelly A, et al.
Publicado: (2017)

miR-29a activates Hes1 by targeting Nfia in esophageal carcinoma cell line TE-1
por: LIU, CHANG, et al.
Publicado: (2015)

NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation
por: Hiraike, Yuta, et al.
Publicado: (2020)

The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53
por: Piqué-Borràs, Maria-Riera, et al.
Publicado: (2023)

Hsa-miR-223-3p participates in the process of anthracycline-induced cardiomyocyte damage by regulating NFIA gene
por: Han, Xiao, et al.
Publicado: (2023)

Pluripotent Stem Cell Therapies for Parkinson Disease: Present Challenges and Future Opportunities
por: Kim, Tae Wan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bqbamaehr648ujvj2d167acqib