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Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans
The periaqueductal gray is a mesencephalic structure involved in modulation of responses to stressful stimuli. Structural connections between the periaqueductal gray and the cerebellum have been described in animals and in a few diffusion tensor imaging studies. Nevertheless, these periaqueductal gr...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591182/ https://www.ncbi.nlm.nih.gov/pubmed/31165919 http://dx.doi.org/10.1007/s00429-019-01893-x |
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author | Cacciola, Alberto Bertino, Salvatore Basile, Gianpaolo Antonio Di Mauro, Debora Calamuneri, Alessandro Chillemi, Gaetana Duca, Antonio Bruschetta, Daniele Flace, Paolo Favaloro, Angelo Calabrò, Rocco Salvatore Anastasi, Giuseppe Milardi, Demetrio |
author_facet | Cacciola, Alberto Bertino, Salvatore Basile, Gianpaolo Antonio Di Mauro, Debora Calamuneri, Alessandro Chillemi, Gaetana Duca, Antonio Bruschetta, Daniele Flace, Paolo Favaloro, Angelo Calabrò, Rocco Salvatore Anastasi, Giuseppe Milardi, Demetrio |
author_sort | Cacciola, Alberto |
collection | PubMed |
description | The periaqueductal gray is a mesencephalic structure involved in modulation of responses to stressful stimuli. Structural connections between the periaqueductal gray and the cerebellum have been described in animals and in a few diffusion tensor imaging studies. Nevertheless, these periaqueductal gray–cerebellum connectivity patterns have yet to be fully investigated in humans. The objective of this study was to qualitatively and quantitatively characterize such pathways using high-resolution, multi-shell data of 100 healthy subjects from the open-access Human Connectome Project repository combined with constrained spherical deconvolution probabilistic tractography. Our analysis revealed robust connectivity density profiles between the periaqueductal gray and cerebellar nuclei, especially with the fastigial nucleus, followed by the interposed and dentate nuclei. High-connectivity densities have been observed between vermal (Vermis IX, Vermis VIIIa, Vermis VIIIb, Vermis VI, Vermis X) and hemispheric cerebellar regions (Lobule IX). Our in vivo study provides for the first time insights on the organization of periaqueductal gray–cerebellar pathways thus opening new perspectives on cognitive, visceral and motor responses to threatening stimuli in humans. |
format | Online Article Text |
id | pubmed-6591182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-65911822019-07-11 Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans Cacciola, Alberto Bertino, Salvatore Basile, Gianpaolo Antonio Di Mauro, Debora Calamuneri, Alessandro Chillemi, Gaetana Duca, Antonio Bruschetta, Daniele Flace, Paolo Favaloro, Angelo Calabrò, Rocco Salvatore Anastasi, Giuseppe Milardi, Demetrio Brain Struct Funct Original Article The periaqueductal gray is a mesencephalic structure involved in modulation of responses to stressful stimuli. Structural connections between the periaqueductal gray and the cerebellum have been described in animals and in a few diffusion tensor imaging studies. Nevertheless, these periaqueductal gray–cerebellum connectivity patterns have yet to be fully investigated in humans. The objective of this study was to qualitatively and quantitatively characterize such pathways using high-resolution, multi-shell data of 100 healthy subjects from the open-access Human Connectome Project repository combined with constrained spherical deconvolution probabilistic tractography. Our analysis revealed robust connectivity density profiles between the periaqueductal gray and cerebellar nuclei, especially with the fastigial nucleus, followed by the interposed and dentate nuclei. High-connectivity densities have been observed between vermal (Vermis IX, Vermis VIIIa, Vermis VIIIb, Vermis VI, Vermis X) and hemispheric cerebellar regions (Lobule IX). Our in vivo study provides for the first time insights on the organization of periaqueductal gray–cerebellar pathways thus opening new perspectives on cognitive, visceral and motor responses to threatening stimuli in humans. Springer Berlin Heidelberg 2019-06-05 2019 /pmc/articles/PMC6591182/ /pubmed/31165919 http://dx.doi.org/10.1007/s00429-019-01893-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Cacciola, Alberto Bertino, Salvatore Basile, Gianpaolo Antonio Di Mauro, Debora Calamuneri, Alessandro Chillemi, Gaetana Duca, Antonio Bruschetta, Daniele Flace, Paolo Favaloro, Angelo Calabrò, Rocco Salvatore Anastasi, Giuseppe Milardi, Demetrio Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans |
title | Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans |
title_full | Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans |
title_fullStr | Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans |
title_full_unstemmed | Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans |
title_short | Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans |
title_sort | mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591182/ https://www.ncbi.nlm.nih.gov/pubmed/31165919 http://dx.doi.org/10.1007/s00429-019-01893-x |
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