Cargando…

Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans

The periaqueductal gray is a mesencephalic structure involved in modulation of responses to stressful stimuli. Structural connections between the periaqueductal gray and the cerebellum have been described in animals and in a few diffusion tensor imaging studies. Nevertheless, these periaqueductal gr...

Descripción completa

Detalles Bibliográficos
Autores principales: Cacciola, Alberto, Bertino, Salvatore, Basile, Gianpaolo Antonio, Di Mauro, Debora, Calamuneri, Alessandro, Chillemi, Gaetana, Duca, Antonio, Bruschetta, Daniele, Flace, Paolo, Favaloro, Angelo, Calabrò, Rocco Salvatore, Anastasi, Giuseppe, Milardi, Demetrio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591182/
https://www.ncbi.nlm.nih.gov/pubmed/31165919
http://dx.doi.org/10.1007/s00429-019-01893-x
_version_ 1783429674741792768
author Cacciola, Alberto
Bertino, Salvatore
Basile, Gianpaolo Antonio
Di Mauro, Debora
Calamuneri, Alessandro
Chillemi, Gaetana
Duca, Antonio
Bruschetta, Daniele
Flace, Paolo
Favaloro, Angelo
Calabrò, Rocco Salvatore
Anastasi, Giuseppe
Milardi, Demetrio
author_facet Cacciola, Alberto
Bertino, Salvatore
Basile, Gianpaolo Antonio
Di Mauro, Debora
Calamuneri, Alessandro
Chillemi, Gaetana
Duca, Antonio
Bruschetta, Daniele
Flace, Paolo
Favaloro, Angelo
Calabrò, Rocco Salvatore
Anastasi, Giuseppe
Milardi, Demetrio
author_sort Cacciola, Alberto
collection PubMed
description The periaqueductal gray is a mesencephalic structure involved in modulation of responses to stressful stimuli. Structural connections between the periaqueductal gray and the cerebellum have been described in animals and in a few diffusion tensor imaging studies. Nevertheless, these periaqueductal gray–cerebellum connectivity patterns have yet to be fully investigated in humans. The objective of this study was to qualitatively and quantitatively characterize such pathways using high-resolution, multi-shell data of 100 healthy subjects from the open-access Human Connectome Project repository combined with constrained spherical deconvolution probabilistic tractography. Our analysis revealed robust connectivity density profiles between the periaqueductal gray and cerebellar nuclei, especially with the fastigial nucleus, followed by the interposed and dentate nuclei. High-connectivity densities have been observed between vermal (Vermis IX, Vermis VIIIa, Vermis VIIIb, Vermis VI, Vermis X) and hemispheric cerebellar regions (Lobule IX). Our in vivo study provides for the first time insights on the organization of periaqueductal gray–cerebellar pathways thus opening new perspectives on cognitive, visceral and motor responses to threatening stimuli in humans.
format Online
Article
Text
id pubmed-6591182
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-65911822019-07-11 Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans Cacciola, Alberto Bertino, Salvatore Basile, Gianpaolo Antonio Di Mauro, Debora Calamuneri, Alessandro Chillemi, Gaetana Duca, Antonio Bruschetta, Daniele Flace, Paolo Favaloro, Angelo Calabrò, Rocco Salvatore Anastasi, Giuseppe Milardi, Demetrio Brain Struct Funct Original Article The periaqueductal gray is a mesencephalic structure involved in modulation of responses to stressful stimuli. Structural connections between the periaqueductal gray and the cerebellum have been described in animals and in a few diffusion tensor imaging studies. Nevertheless, these periaqueductal gray–cerebellum connectivity patterns have yet to be fully investigated in humans. The objective of this study was to qualitatively and quantitatively characterize such pathways using high-resolution, multi-shell data of 100 healthy subjects from the open-access Human Connectome Project repository combined with constrained spherical deconvolution probabilistic tractography. Our analysis revealed robust connectivity density profiles between the periaqueductal gray and cerebellar nuclei, especially with the fastigial nucleus, followed by the interposed and dentate nuclei. High-connectivity densities have been observed between vermal (Vermis IX, Vermis VIIIa, Vermis VIIIb, Vermis VI, Vermis X) and hemispheric cerebellar regions (Lobule IX). Our in vivo study provides for the first time insights on the organization of periaqueductal gray–cerebellar pathways thus opening new perspectives on cognitive, visceral and motor responses to threatening stimuli in humans. Springer Berlin Heidelberg 2019-06-05 2019 /pmc/articles/PMC6591182/ /pubmed/31165919 http://dx.doi.org/10.1007/s00429-019-01893-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Cacciola, Alberto
Bertino, Salvatore
Basile, Gianpaolo Antonio
Di Mauro, Debora
Calamuneri, Alessandro
Chillemi, Gaetana
Duca, Antonio
Bruschetta, Daniele
Flace, Paolo
Favaloro, Angelo
Calabrò, Rocco Salvatore
Anastasi, Giuseppe
Milardi, Demetrio
Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans
title Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans
title_full Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans
title_fullStr Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans
title_full_unstemmed Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans
title_short Mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans
title_sort mapping the structural connectivity between the periaqueductal gray and the cerebellum in humans
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591182/
https://www.ncbi.nlm.nih.gov/pubmed/31165919
http://dx.doi.org/10.1007/s00429-019-01893-x
work_keys_str_mv AT cacciolaalberto mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT bertinosalvatore mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT basilegianpaoloantonio mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT dimaurodebora mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT calamunerialessandro mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT chillemigaetana mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT ducaantonio mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT bruschettadaniele mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT flacepaolo mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT favaloroangelo mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT calabroroccosalvatore mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT anastasigiuseppe mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans
AT milardidemetrio mappingthestructuralconnectivitybetweentheperiaqueductalgrayandthecerebelluminhumans