Role of network-mediated stochasticity in mammalian drug resistance

A major challenge in biology is that genetically identical cells in the same environment can display gene expression stochasticity (noise), which contributes to bet-hedging, drug tolerance, and cell-fate switching. The magnitude and timescales of stochastic fluctuations can depend on the gene regula...

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Detalles Bibliográficos
Autores principales: Farquhar, Kevin S., Charlebois, Daniel A., Szenk, Mariola, Cohen, Joseph, Nevozhay, Dmitry, Balázsi, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591227/
https://www.ncbi.nlm.nih.gov/pubmed/31235692
http://dx.doi.org/10.1038/s41467-019-10330-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591227/
https://www.ncbi.nlm.nih.gov/pubmed/31235692
http://dx.doi.org/10.1038/s41467-019-10330-w

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