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Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment

The transient receptor potential ion-channel superfamily consists of nonselective cation channels located mostly on the plasma membranes of numerous animal cell types, which are closely related to sensory information transmission (e.g., vision, pain, and temperature perception), as well as regulatio...

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Autores principales: Yu, Suyun, Huang, Shuai, Ding, Yushi, Wang, Wei, Wang, Aiyun, Lu, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591233/
https://www.ncbi.nlm.nih.gov/pubmed/31235786
http://dx.doi.org/10.1038/s41419-019-1708-9
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author Yu, Suyun
Huang, Shuai
Ding, Yushi
Wang, Wei
Wang, Aiyun
Lu, Yin
author_facet Yu, Suyun
Huang, Shuai
Ding, Yushi
Wang, Wei
Wang, Aiyun
Lu, Yin
author_sort Yu, Suyun
collection PubMed
description The transient receptor potential ion-channel superfamily consists of nonselective cation channels located mostly on the plasma membranes of numerous animal cell types, which are closely related to sensory information transmission (e.g., vision, pain, and temperature perception), as well as regulation of intracellular Ca(2+) balance and physiological activities of growth and development. Transient receptor potential ion channel subfamily V (TRPV) is one of the largest and most diverse subfamilies, including TRPV1–TRPV6 involved in the regulation of a variety of cellular functions. TRPV4 can be activated by various physical and chemical stimuli, such as heat, mechanical force, and phorbol ester derivatives participating in the maintenance of normal cellular functions. In recent years, the roles of TRPV4 in cell proliferation, differentiation, apoptosis, and migration have been extensively studied. Its abnormal expression has also been closely related to the onset and progression of multiple tumors, so TRPV4 may be a target for cancer diagnosis and treatment. In this review, we focused on the latest studies concerning the role of TRPV4 in tumorigenesis and the therapeutic potential. As evidenced by the effects on cancerogenesis, TRPV4 is a potential target for anticancer therapy.
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spelling pubmed-65912332019-06-25 Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment Yu, Suyun Huang, Shuai Ding, Yushi Wang, Wei Wang, Aiyun Lu, Yin Cell Death Dis Review Article The transient receptor potential ion-channel superfamily consists of nonselective cation channels located mostly on the plasma membranes of numerous animal cell types, which are closely related to sensory information transmission (e.g., vision, pain, and temperature perception), as well as regulation of intracellular Ca(2+) balance and physiological activities of growth and development. Transient receptor potential ion channel subfamily V (TRPV) is one of the largest and most diverse subfamilies, including TRPV1–TRPV6 involved in the regulation of a variety of cellular functions. TRPV4 can be activated by various physical and chemical stimuli, such as heat, mechanical force, and phorbol ester derivatives participating in the maintenance of normal cellular functions. In recent years, the roles of TRPV4 in cell proliferation, differentiation, apoptosis, and migration have been extensively studied. Its abnormal expression has also been closely related to the onset and progression of multiple tumors, so TRPV4 may be a target for cancer diagnosis and treatment. In this review, we focused on the latest studies concerning the role of TRPV4 in tumorigenesis and the therapeutic potential. As evidenced by the effects on cancerogenesis, TRPV4 is a potential target for anticancer therapy. Nature Publishing Group UK 2019-06-24 /pmc/articles/PMC6591233/ /pubmed/31235786 http://dx.doi.org/10.1038/s41419-019-1708-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Yu, Suyun
Huang, Shuai
Ding, Yushi
Wang, Wei
Wang, Aiyun
Lu, Yin
Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment
title Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment
title_full Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment
title_fullStr Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment
title_full_unstemmed Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment
title_short Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment
title_sort transient receptor potential ion-channel subfamily v member 4: a potential target for cancer treatment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591233/
https://www.ncbi.nlm.nih.gov/pubmed/31235786
http://dx.doi.org/10.1038/s41419-019-1708-9
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