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Disease-linked mutations alter the stoichiometries of HCN-KCNE2 complexes

The four hyperpolarization-activated cylic-nucleotide gated (HCN) channel isoforms and their auxiliary subunit KCNE2 are important in the regulation of peripheral and central neuronal firing and the heartbeat. Disruption of their normal function has been implicated in cardiac arrhythmias, peripheral...

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Detalles Bibliográficos
Autores principales:	Lussier, Yoann, Fürst, Oliver, Fortea, Eva, Leclerc, Marc, Priolo, Dimitri, Moeller, Lena, Bichet, Daniel G., Blunck, Rikard, D’Avanzo, Nazzareno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591248/ https://www.ncbi.nlm.nih.gov/pubmed/31235733 http://dx.doi.org/10.1038/s41598-019-45592-3

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