In vivo measurements reveal a single 5′-intron is sufficient to increase protein expression level in Caenorhabditis elegans

Introns can increase gene expression levels using a variety of mechanisms collectively referred to as Intron Mediated Enhancement (IME). IME has been measured in cell culture and plant models by quantifying expression of intronless and intron-bearing reporter genes in vitro. We developed hardware an...

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Detalles Bibliográficos
Autores principales: Crane, Matthew M., Sands, Bryan, Battaglia, Christian, Johnson, Brock, Yun, Soo, Kaeberlein, Matt, Brent, Roger, Mendenhall, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591249/
https://www.ncbi.nlm.nih.gov/pubmed/31235724
http://dx.doi.org/10.1038/s41598-019-45517-0

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