Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis

Necroptosis is a form of regulated necrosis controlled by receptor-interacting kinase 1 (RIPK1 or RIP1), RIPK3 (RIP3), and pseudokinase mixed lineage kinase domain-like protein (MLKL). Increasing evidence suggests that necroptosis is closely associated with pathologies including inflammatory disease...

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Detalles Bibliográficos
Autores principales: Hou, Jue, Ju, Jie, Zhang, Zili, Zhao, Cong, Li, Zhanhui, Zheng, Jiyue, Sheng, Tian, Zhang, Hongjian, Hu, Linkun, Yu, Xiaoliang, Zhang, Wei, Li, Yangxin, Wu, Meng, Ma, Haikuo, Zhang, Xiaohu, He, Sudan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591251/
https://www.ncbi.nlm.nih.gov/pubmed/31235688
http://dx.doi.org/10.1038/s41419-019-1735-6

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