The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload

Left ventricular (LV) dilatation is a key step in transition to heart failure (HF) in response to pressure overload. Cardiac extracellular matrix (ECM) contains fibrillar collagens and proteoglycans, important for maintaining tissue integrity. Alterations in collagen production and cross-linking are...

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Detalles Bibliográficos
Autores principales: Mohammadzadeh, Naiyereh, Lunde, Ida G., Andenæs, Kine, Strand, Mari E., Aronsen, Jan Magnus, Skrbic, Biljana, Marstein, Henriette S., Bandlien, Caroline, Nygård, Ståle, Gorham, Joshua, Sjaastad, Ivar, Chakravarti, Shukti, Christensen, Geir, Engebretsen, Kristin V. T., Tønnessen, Theis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591256/
https://www.ncbi.nlm.nih.gov/pubmed/31235849
http://dx.doi.org/10.1038/s41598-019-45651-9

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