Cargando…

The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review

Identifying appropriate animal models is critical in developing translatable in vitro and in vivo systems for therapeutic drug development and investigating disease pathophysiology. These animal models should have direct biological and translational relevance to the underlying disease they are suppo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ambrosini, Yoko M., Borcherding, Dana, Kanthasamy, Anumantha, Kim, Hyun Jung, Willette, Auriel A., Jergens, Albert, Allenspach, Karin, Mochel, Jonathan P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591269/ https://www.ncbi.nlm.nih.gov/pubmed/31275138 http://dx.doi.org/10.3389/fnagi.2019.00130

Ejemplares similares

Treatment With Hydrolyzed Diet Supplemented With Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in Canine Inflammatory Bowel Disease
por: Ambrosini, Yoko M., et al.
Publicado: (2020)

Recapitulation of the accessible interface of biopsy-derived canine intestinal organoids to study epithelial-luminal interactions
por: Ambrosini, Yoko M., et al.
Publicado: (2020)

Derivation of adult canine intestinal organoids for translational research in gastroenterology
por: Chandra, Lawrance, et al.
Publicado: (2019)

Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti‐tumourigenic effects: A model for human ketotherapy trials
por: Allenspach, Karin, et al.
Publicado: (2022)

Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease
por: Atherly, Todd, et al.
Publicado: (2019)

Harnessing the Biology of Canine Intestinal Organoids to Heighten Understanding of Inflammatory Bowel Disease Pathogenesis and Accelerate Drug Discovery: A One Health Approach
por: Kopper, Jamie J., et al.
Publicado: (2021)

Differential Transcriptomic Profiles Following Stimulation with Lipopolysaccharide in Intestinal Organoids from Dogs with Inflammatory Bowel Disease and Intestinal Mast Cell Tumor
por: Sahoo, Dipak Kumar, et al.
Publicado: (2022)

Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research
por: Mochel, Jonathan P., et al.
Publicado: (2017)

Apparent total tract digestibility, fecal characteristics, and blood parameters of healthy adult dogs fed high-fat diets
por: Kilburn, Logan R, et al.
Publicado: (2020)

Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders
por: Padhi, Piyush, et al.
Publicado: (2022)

Using machine learning to predict COVID-19 infection and severity risk among 4510 aged adults: a UK Biobank cohort study
por: Willette, Auriel A., et al.
Publicado: (2022)

Model‐Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative
por: Schneider, Benjamin, et al.
Publicado: (2017)

CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors
por: Pappas, Colleen, et al.
Publicado: (2020)

Canine Intestinal Organoids as a Novel In Vitro Model of Intestinal Drug Permeability: A Proof-of-Concept Study
por: Sahoo, Dipak Kumar, et al.
Publicado: (2023)

Interleukin‐13 and interleukin‐33 mRNA are underexpressed in the duodenal mucosa of German Shepherd dogs with chronic enteropathy
por: Kathrani, Aarti, et al.
Publicado: (2019)

Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy
por: Kathrani, Aarti, et al.
Publicado: (2019)

Gut, Microbiome, and Brain Regulatory Axis: Relevance to Neurodegenerative and Psychiatric Disorders
por: Stefano, G. B., et al.
Publicado: (2018)

Interleukin-1β expression is increased in the duodenum of dogs with idiopathic inflammatory bowel disease
por: Hawes, Martin, et al.
Publicado: (2018)

Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of gastrointestinal stromal tumors of dogs
por: Berger, Erika P., et al.
Publicado: (2018)

Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease
por: Panicker, Nikhil, et al.
Publicado: (2019)

OrganoidChip facilitates hydrogel-free immobilization for fast and blur-free imaging of organoids
por: Moshksayan, Khashayar, et al.
Publicado: (2023)

Culture and characterization of canine and feline corneal epithelial organoids: A new tool for the study and treatment of corneal diseases
por: Bedos, Leila, et al.
Publicado: (2022)

Colonic mucosal and cytobrush sample cytokine mRNA expression in canine inflammatory bowel disease and their correlation with disease activity, endoscopic and histopathologic score
por: Konstantinidis, Alexandros O., et al.
Publicado: (2021)

Microbiota-Related Changes in Unconjugated Fecal Bile Acids Are Associated With Naturally Occurring, Insulin-Dependent Diabetes Mellitus in Dogs
por: Jergens, Albert E., et al.
Publicado: (2019)

Colonic mucosal and serum expression of microRNAs in canine large intestinal inflammatory bowel disease
por: Konstantinidis, Alexandros Ο., et al.
Publicado: (2020)

Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation
por: Gordon, Richard, et al.
Publicado: (2012)

Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology
por: Malovic, Emir, et al.
Publicado: (2021)

Canine chronic enteropathy—Current state-of-the-art and emerging concepts
por: Jergens, Albert E., et al.
Publicado: (2022)

Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease
por: Kanthasamy, Anumantha G, et al.
Publicado: (2008)

Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration
por: Asaithambi, Arunkumar, et al.
Publicado: (2011)

N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells
por: Chandramani Shivalingappa, Prashanth, et al.
Publicado: (2012)

Neuroprotective Effect of Resveratrol Against Methamphetamine-Induced Dopaminergic Apoptotic Cell Death in a Cell Culture Model of Neurotoxicity
por: Kanthasamy, Kavin, et al.
Publicado: (2011)

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson’s Disease
por: Samidurai, Manikandan, et al.
Publicado: (2020)

Insulin Resistance Predicts Medial Temporal Hypermetabolism in Mild Cognitive Impairment Conversion to Alzheimer Disease
por: Willette, Auriel A., et al.
Publicado: (2015)

Convergent pathways of the gut microbiota–brain axis and neurodegenerative disorders
por: Gubert, Carolina, et al.
Publicado: (2022)

Neurodegenerative diseases: from gut-brain axis to brain microbiome
por: Friedland, Robert P., et al.
Publicado: (2023)

Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCδ proteolytic activation and mitochondrial translocation
por: Sun, Faneng, et al.
Publicado: (2008)

Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model
por: Xu, Qi, et al.
Publicado: (2011)

EGCG Protects against 6-OHDA-Induced Neurotoxicity in a Cell Culture Model
por: Chen, Dan, et al.
Publicado: (2015)

Genome-wide association studies of inflammatory bowel disease in German shepherd dogs
por: Peiravan, Atiyeh, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_h0vt17r0o9lrlive7mvsi3sh1c