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Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction

Biophysical cues influence many aspects of cell behavior. Stiffness of the extracellular matrix is probed by cells and transduced into biochemical signals through mechanotransduction protein networks, strongly influencing stem cell behavior. Cellular stemness is intimately related with mechanical pr...

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Detalles Bibliográficos
Autores principales:	Gerardo, Heloísa, Lima, Ana, Carvalho, João, Ramos, João R. D., Couceiro, Sofia, Travasso, Rui D. M., Pires das Neves, Ricardo, Grãos, Mário
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591285/ https://www.ncbi.nlm.nih.gov/pubmed/31235788 http://dx.doi.org/10.1038/s41598-019-45352-3

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