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Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then co...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591304/ https://www.ncbi.nlm.nih.gov/pubmed/31235808 http://dx.doi.org/10.1038/s41467-019-10630-1 |
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author | Shungin, Dmitry Haworth, Simon Divaris, Kimon Agler, Cary S. Kamatani, Yoichiro Keun Lee, Myoung Grinde, Kelsey Hindy, George Alaraudanjoki, Viivi Pesonen, Paula Teumer, Alexander Holtfreter, Birte Sakaue, Saori Hirata, Jun Yu, Yau-Hua Ridker, Paul M. Giulianini, Franco Chasman, Daniel I. Magnusson, Patrik K. E. Sudo, Takeaki Okada, Yukinori Völker, Uwe Kocher, Thomas Anttonen, Vuokko Laitala, Marja-Liisa Orho-Melander, Marju Sofer, Tamar Shaffer, John R. Vieira, Alexandre Marazita, Mary L. Kubo, Michiaki Furuichi, Yasushi North, Kari E. Offenbacher, Steve Ingelsson, Erik Franks, Paul W. Timpson, Nicholas J. Johansson, Ingegerd |
author_facet | Shungin, Dmitry Haworth, Simon Divaris, Kimon Agler, Cary S. Kamatani, Yoichiro Keun Lee, Myoung Grinde, Kelsey Hindy, George Alaraudanjoki, Viivi Pesonen, Paula Teumer, Alexander Holtfreter, Birte Sakaue, Saori Hirata, Jun Yu, Yau-Hua Ridker, Paul M. Giulianini, Franco Chasman, Daniel I. Magnusson, Patrik K. E. Sudo, Takeaki Okada, Yukinori Völker, Uwe Kocher, Thomas Anttonen, Vuokko Laitala, Marja-Liisa Orho-Melander, Marju Sofer, Tamar Shaffer, John R. Vieira, Alexandre Marazita, Mary L. Kubo, Michiaki Furuichi, Yasushi North, Kari E. Offenbacher, Steve Ingelsson, Erik Franks, Paul W. Timpson, Nicholas J. Johansson, Ingegerd |
author_sort | Shungin, Dmitry |
collection | PubMed |
description | Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health. |
format | Online Article Text |
id | pubmed-6591304 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65913042019-06-26 Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data Shungin, Dmitry Haworth, Simon Divaris, Kimon Agler, Cary S. Kamatani, Yoichiro Keun Lee, Myoung Grinde, Kelsey Hindy, George Alaraudanjoki, Viivi Pesonen, Paula Teumer, Alexander Holtfreter, Birte Sakaue, Saori Hirata, Jun Yu, Yau-Hua Ridker, Paul M. Giulianini, Franco Chasman, Daniel I. Magnusson, Patrik K. E. Sudo, Takeaki Okada, Yukinori Völker, Uwe Kocher, Thomas Anttonen, Vuokko Laitala, Marja-Liisa Orho-Melander, Marju Sofer, Tamar Shaffer, John R. Vieira, Alexandre Marazita, Mary L. Kubo, Michiaki Furuichi, Yasushi North, Kari E. Offenbacher, Steve Ingelsson, Erik Franks, Paul W. Timpson, Nicholas J. Johansson, Ingegerd Nat Commun Article Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health. Nature Publishing Group UK 2019-06-24 /pmc/articles/PMC6591304/ /pubmed/31235808 http://dx.doi.org/10.1038/s41467-019-10630-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Shungin, Dmitry Haworth, Simon Divaris, Kimon Agler, Cary S. Kamatani, Yoichiro Keun Lee, Myoung Grinde, Kelsey Hindy, George Alaraudanjoki, Viivi Pesonen, Paula Teumer, Alexander Holtfreter, Birte Sakaue, Saori Hirata, Jun Yu, Yau-Hua Ridker, Paul M. Giulianini, Franco Chasman, Daniel I. Magnusson, Patrik K. E. Sudo, Takeaki Okada, Yukinori Völker, Uwe Kocher, Thomas Anttonen, Vuokko Laitala, Marja-Liisa Orho-Melander, Marju Sofer, Tamar Shaffer, John R. Vieira, Alexandre Marazita, Mary L. Kubo, Michiaki Furuichi, Yasushi North, Kari E. Offenbacher, Steve Ingelsson, Erik Franks, Paul W. Timpson, Nicholas J. Johansson, Ingegerd Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data |
title | Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data |
title_full | Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data |
title_fullStr | Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data |
title_full_unstemmed | Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data |
title_short | Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data |
title_sort | genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591304/ https://www.ncbi.nlm.nih.gov/pubmed/31235808 http://dx.doi.org/10.1038/s41467-019-10630-1 |
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