Endothelial cell clonal expansion in the development of cerebral cavernous malformations

Cerebral cavernous malformation (CCM) is a neurovascular familial or sporadic disease that is characterised by capillary-venous cavernomas, and is due to loss-of-function mutations to any one of three CCM genes. Familial CCM follows a two-hit mechanism similar to that of tumour suppressor genes, whi...

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Detalles Bibliográficos
Autores principales: Malinverno, Matteo, Maderna, Claudio, Abu Taha, Abdallah, Corada, Monica, Orsenigo, Fabrizio, Valentino, Mariaelena, Pisati, Federica, Fusco, Carmela, Graziano, Paolo, Giannotta, Monica, Yu, Qing Cissy, Zeng, Yi Arial, Lampugnani, Maria Grazia, Magnusson, Peetra U., Dejana, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591323/
https://www.ncbi.nlm.nih.gov/pubmed/31235698
http://dx.doi.org/10.1038/s41467-019-10707-x

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