Cargando…
Left hemisphere enhancement of auditory activation in language impaired children
Specific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591383/ https://www.ncbi.nlm.nih.gov/pubmed/31235763 http://dx.doi.org/10.1038/s41598-019-45597-y |
_version_ | 1783429719094460416 |
---|---|
author | van Bijnen, Sam Kärkkäinen, Salme Helenius, Päivi Parviainen, Tiina |
author_facet | van Bijnen, Sam Kärkkäinen, Salme Helenius, Päivi Parviainen, Tiina |
author_sort | van Bijnen, Sam |
collection | PubMed |
description | Specific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language skills. We recorded auditory responses evoked by sine-wave tones presented alternately to the right and left ear of 9–10-year-old children with SLI (n = 10) and children with typical language development (n = 10). Source analysis was used to isolate the N250m response in the left and right hemisphere. In children with language impairment left-hemisphere N250m responses were enhanced compared to those of controls, while no group difference was found in the right hemisphere. Consequently, language impaired children lacked the typical right-ward asymmetry that was found in control children. Furthermore, left but not right hemisphere N250m responses correlated positively with performance on a phonological processing task in the SLI group exclusively, possibly signifying a compensatory mechanism for delayed maturation of language processing. These results suggest that enhanced left-hemisphere auditory activation reflects a core neurophysiological manifestation of developmental language disorders, and emphasize the relevance of this developmentally specific activation pattern for competent language development. |
format | Online Article Text |
id | pubmed-6591383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65913832019-07-02 Left hemisphere enhancement of auditory activation in language impaired children van Bijnen, Sam Kärkkäinen, Salme Helenius, Päivi Parviainen, Tiina Sci Rep Article Specific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language skills. We recorded auditory responses evoked by sine-wave tones presented alternately to the right and left ear of 9–10-year-old children with SLI (n = 10) and children with typical language development (n = 10). Source analysis was used to isolate the N250m response in the left and right hemisphere. In children with language impairment left-hemisphere N250m responses were enhanced compared to those of controls, while no group difference was found in the right hemisphere. Consequently, language impaired children lacked the typical right-ward asymmetry that was found in control children. Furthermore, left but not right hemisphere N250m responses correlated positively with performance on a phonological processing task in the SLI group exclusively, possibly signifying a compensatory mechanism for delayed maturation of language processing. These results suggest that enhanced left-hemisphere auditory activation reflects a core neurophysiological manifestation of developmental language disorders, and emphasize the relevance of this developmentally specific activation pattern for competent language development. Nature Publishing Group UK 2019-06-24 /pmc/articles/PMC6591383/ /pubmed/31235763 http://dx.doi.org/10.1038/s41598-019-45597-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article van Bijnen, Sam Kärkkäinen, Salme Helenius, Päivi Parviainen, Tiina Left hemisphere enhancement of auditory activation in language impaired children |
title | Left hemisphere enhancement of auditory activation in language impaired children |
title_full | Left hemisphere enhancement of auditory activation in language impaired children |
title_fullStr | Left hemisphere enhancement of auditory activation in language impaired children |
title_full_unstemmed | Left hemisphere enhancement of auditory activation in language impaired children |
title_short | Left hemisphere enhancement of auditory activation in language impaired children |
title_sort | left hemisphere enhancement of auditory activation in language impaired children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591383/ https://www.ncbi.nlm.nih.gov/pubmed/31235763 http://dx.doi.org/10.1038/s41598-019-45597-y |
work_keys_str_mv | AT vanbijnensam lefthemisphereenhancementofauditoryactivationinlanguageimpairedchildren AT karkkainensalme lefthemisphereenhancementofauditoryactivationinlanguageimpairedchildren AT heleniuspaivi lefthemisphereenhancementofauditoryactivationinlanguageimpairedchildren AT parviainentiina lefthemisphereenhancementofauditoryactivationinlanguageimpairedchildren |