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Clonality of CD4(+) Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma

Recognition of cancer antigens drives the clonal expansion of cancer-reactive T cells, which is thought to contribute to restricted T-cell receptor (TCR) repertoires in tumor-infiltrating lymphocytes (TILs). To understand how tumors escape anti-tumor immunity, we investigated tumor-associated T-cell...

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Detalles Bibliográficos
Autores principales:	Arakawa, Akiko, Vollmer, Sigrid, Tietze, Julia, Galinski, Adrian, Heppt, Markus V., Bürdek, Maja, Berking, Carola, Prinz, Jörg C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591437/ https://www.ncbi.nlm.nih.gov/pubmed/31275310 http://dx.doi.org/10.3389/fimmu.2019.01336

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