Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure

Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from transplant center operating rooms, and obtain genome-wide genotyping and gene expression m...

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Detalles Bibliográficos
Autores principales: Cordero, Pablo, Parikh, Victoria N., Chin, Elizabeth T., Erbilgin, Ayca, Gloudemans, Michael J., Shang, Ching, Huang, Yong, Chang, Alex C., Smith, Kevin S., Dewey, Frederick, Zaleta, Kathia, Morley, Michael, Brandimarto, Jeff, Glazer, Nicole, Waggott, Daryl, Pavlovic, Aleksandra, Zhao, Mingming, Moravec, Christine S., Tang, W. H. Wilson, Skreen, Jamie, Malloy, Christine, Hannenhalli, Sridhar, Li, Hongzhe, Ritter, Scott, Li, Mingyao, Bernstein, Daniel, Connolly, Andrew, Hakonarson, Hakon, Lusis, Aldons J., Margulies, Kenneth B., Depaoli-Roach, Anna A., Montgomery, Stephen B., Wheeler, Matthew T., Cappola, Thomas, Ashley, Euan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591478/
https://www.ncbi.nlm.nih.gov/pubmed/31235787
http://dx.doi.org/10.1038/s41467-019-10591-5

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