Cargando…

Shank3 Mice Carrying the Human Q321R Mutation Display Enhanced Self-Grooming, Abnormal Electroencephalogram Patterns, and Suppressed Neuronal Excitability and Seizure Susceptibility

Shank3, a postsynaptic scaffolding protein involved in regulating excitatory synapse assembly and function, has been implicated in several brain disorders, including autism spectrum disorders (ASD), Phelan-McDermid syndrome, schizophrenia, intellectual disability, and mania. Here we generated and ch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoo, Ye-Eun, Yoo, Taesun, Lee, Seungjoon, Lee, Jiseok, Kim, Doyoun, Han, Hye-Min, Bae, Yong-Chul, Kim, Eunjoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591539/ https://www.ncbi.nlm.nih.gov/pubmed/31275112 http://dx.doi.org/10.3389/fnmol.2019.00155

Ejemplares similares

Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice
por: Lee, Seungjoon, et al.
Publicado: (2018)

Shank3 Exons 14–16 Deletion in Glutamatergic Neurons Leads to Social and Repetitive Behavioral Deficits Associated With Increased Cortical Layer 2/3 Neuronal Excitability
por: Yoo, Taesun, et al.
Publicado: (2019)

GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities
por: Yoo, Taesun, et al.
Publicado: (2018)

Brain region and gene dosage-differential transcriptomic changes in Shank2-mutant mice
por: Yoo, Ye-Eun, et al.
Publicado: (2022)

Age, brain region, and gene dosage-differential transcriptomic changes in Shank3-mutant mice
por: Yoo, Taesun, et al.
Publicado: (2022)

Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit
por: Lee, Jiseok, et al.
Publicado: (2015)

Gene Dosage- and Age-Dependent Differential Transcriptomic Changes in the Prefrontal Cortex of Shank2-Mutant Mice
por: Lee, Seungjoon, et al.
Publicado: (2021)

Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice
por: Yoo, Ye-Eun, et al.
Publicado: (2021)

The Neomycin Resistance Cassette in the Targeted Allele of Shank3B Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform
por: Jin, Chunmei, et al.
Publicado: (2021)

Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice
por: Lee, Eunee, et al.
Publicado: (2021)

Clmp Regulates AMPA and Kainate Receptor Responses in the Neonatal Hippocampal CA3 and Kainate Seizure Susceptibility in Mice
por: Jang, Seil, et al.
Publicado: (2020)

Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling
por: Lee, Yeunkum, et al.
Publicado: (2017)

Enhanced fear limits behavioral flexibility in Shank2-deficient mice
por: Yun, Miru, et al.
Publicado: (2022)

Correction: Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits
por: Cho, Heejin, et al.
Publicado: (2023)

Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits
por: Cho, Heejin, et al.
Publicado: (2023)

Editorial: Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases
por: Ey, Elodie, et al.
Publicado: (2020)

Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of Shank3 mutant mice
por: Ferhat, Allain-Thibeault, et al.
Publicado: (2023)

Focal Seizures Induced by Intracranial Electroencephalogram Grids
por: Hudgins, Eric, et al.
Publicado: (2016)

GroomRL: jet grooming through reinforcement learning
por: Dreyer, Frederic Alexandre
Publicado: (2019)

A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum
por: Yoo, Taesun, et al.
Publicado: (2020)

3293 Region Specific Dysregulation of Dopaminergic Signaling in Mice Displaying Excessive Over-Grooming
por: Foster, Daniel, et al.
Publicado: (2019)

Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background
por: Jin, Chunmei, et al.
Publicado: (2018)

Multiscale Entropy of Electroencephalogram as a Potential Predictor for the Prognosis of Neonatal Seizures
por: Lu, Wen-Yu, et al.
Publicado: (2015)

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice
por: Oh, Hyoseon, et al.
Publicado: (2023)

Autosomal dominant transmission of complicated hereditary spastic paraplegia due to a dominant negative mutation of KIF1A, SPG30 gene
por: Cheon, Chong Kun, et al.
Publicado: (2017)

Jet Grooming at ATLAS
por: Thompson, E N
Publicado: (2012)

English Groom and Yankee
Publicado: (1874)

Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model
por: Liu, Haiying, et al.
Publicado: (2021)

Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory
por: Shin, Wangyong, et al.
Publicado: (2019)

Whom to Groom and for What? Patterns of Grooming in Female Barbary Macaques (Macaca sylvanus)
por: Roubová, Veronika, et al.
Publicado: (2015)

Predictors of abnormal electroencephalogram and neuroimaging in children presenting to the emergency department with new-onset afebrile seizures
por: Ali, Noman, et al.
Publicado: (2022)

Seizure detection with reduced electroencephalogram channels: research trends and outlook
por: Maher, Christina, et al.
Publicado: (2023)

Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations
por: Lee, Yeunkum, et al.
Publicado: (2017)

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
por: Peça, João, et al.
Publicado: (2011)

A Case of Habitual Neck Compression Induced Electroencephalogram Abnormalities: Differentiating from Epileptic Seizures Using a Tc-99m HMPAO SPECT
por: Choi, Hongyoon, et al.
Publicado: (2014)

Evaluation of Seizure Frequency Distribution in Epileptic Patients with Normal and Abnormal Electroencephalogram in Al-Zahra Hospital of Isfahan
por: Najafi, Mohmmad Reza, et al.
Publicado: (2018)

Pileup mitigation and grooming (theory)
por: Alipour-fard, Samuel
Publicado: (2022)

The (In)visibility of Groomed Ski Runs
por: Harrison, William J.
Publicado: (2019)

A groom with a view
por: Markowitz, Jeffrey E
Publicado: (2023)

Detecting epileptic seizures with electroencephalogram via a context-learning model
por: Xun, Guangxu, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_cfd9i0afok32ogscger3351tk7