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The emerging role of circular RNAs in breast cancer

Breast cancer (BCa) is one of the most frequently diagnosed cancers and leading cause of cancer deaths among females worldwide. Circular RNAs (circRNAs) are a new class of endogenous regulatory RNAs characterized by circular shape resulting from covalently closed continuous loops that are capable of...

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Autores principales: Zhou, Si-ying, Chen, Wei, Yang, Su-jin, Xu, Zi-han, Hu, Jia-hua, Zhang, He-da, Zhong, Shan-liang, Tang, Jin-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591565/
https://www.ncbi.nlm.nih.gov/pubmed/31160488
http://dx.doi.org/10.1042/BSR20190621
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author Zhou, Si-ying
Chen, Wei
Yang, Su-jin
Xu, Zi-han
Hu, Jia-hua
Zhang, He-da
Zhong, Shan-liang
Tang, Jin-hai
author_facet Zhou, Si-ying
Chen, Wei
Yang, Su-jin
Xu, Zi-han
Hu, Jia-hua
Zhang, He-da
Zhong, Shan-liang
Tang, Jin-hai
author_sort Zhou, Si-ying
collection PubMed
description Breast cancer (BCa) is one of the most frequently diagnosed cancers and leading cause of cancer deaths among females worldwide. Circular RNAs (circRNAs) are a new class of endogenous regulatory RNAs characterized by circular shape resulting from covalently closed continuous loops that are capable of regulating gene expression at transcription or post-transcription levels. With the unique structures, circRNAs are resistant to exonuclease RNase R and maintain stability more easily than linear RNAs. Recently, an increasing number of circRNAs are discovered and reported to show different expression in BCa and these dysregulated circRNAs were correlated with patients’ clinical characteristics and grade in the progression of BCa. CircRNAs participate in the bioprocesses of carcinogenesis of BCa, including cell proliferation, apoptosis, cell cycle, tumorigenesis, vascularization, cell invasion, migration as well as metastasis. Here we concentrated on biogenesis and function of circRNAs, summarized their implications in BCa and discussed their potential as diagnostic and therapeutic targets for BCa.
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spelling pubmed-65915652019-06-27 The emerging role of circular RNAs in breast cancer Zhou, Si-ying Chen, Wei Yang, Su-jin Xu, Zi-han Hu, Jia-hua Zhang, He-da Zhong, Shan-liang Tang, Jin-hai Biosci Rep Review Articles Breast cancer (BCa) is one of the most frequently diagnosed cancers and leading cause of cancer deaths among females worldwide. Circular RNAs (circRNAs) are a new class of endogenous regulatory RNAs characterized by circular shape resulting from covalently closed continuous loops that are capable of regulating gene expression at transcription or post-transcription levels. With the unique structures, circRNAs are resistant to exonuclease RNase R and maintain stability more easily than linear RNAs. Recently, an increasing number of circRNAs are discovered and reported to show different expression in BCa and these dysregulated circRNAs were correlated with patients’ clinical characteristics and grade in the progression of BCa. CircRNAs participate in the bioprocesses of carcinogenesis of BCa, including cell proliferation, apoptosis, cell cycle, tumorigenesis, vascularization, cell invasion, migration as well as metastasis. Here we concentrated on biogenesis and function of circRNAs, summarized their implications in BCa and discussed their potential as diagnostic and therapeutic targets for BCa. Portland Press Ltd. 2019-06-25 /pmc/articles/PMC6591565/ /pubmed/31160488 http://dx.doi.org/10.1042/BSR20190621 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Zhou, Si-ying
Chen, Wei
Yang, Su-jin
Xu, Zi-han
Hu, Jia-hua
Zhang, He-da
Zhong, Shan-liang
Tang, Jin-hai
The emerging role of circular RNAs in breast cancer
title The emerging role of circular RNAs in breast cancer
title_full The emerging role of circular RNAs in breast cancer
title_fullStr The emerging role of circular RNAs in breast cancer
title_full_unstemmed The emerging role of circular RNAs in breast cancer
title_short The emerging role of circular RNAs in breast cancer
title_sort emerging role of circular rnas in breast cancer
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591565/
https://www.ncbi.nlm.nih.gov/pubmed/31160488
http://dx.doi.org/10.1042/BSR20190621
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