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The emerging role of circular RNAs in breast cancer
Breast cancer (BCa) is one of the most frequently diagnosed cancers and leading cause of cancer deaths among females worldwide. Circular RNAs (circRNAs) are a new class of endogenous regulatory RNAs characterized by circular shape resulting from covalently closed continuous loops that are capable of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591565/ https://www.ncbi.nlm.nih.gov/pubmed/31160488 http://dx.doi.org/10.1042/BSR20190621 |
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author | Zhou, Si-ying Chen, Wei Yang, Su-jin Xu, Zi-han Hu, Jia-hua Zhang, He-da Zhong, Shan-liang Tang, Jin-hai |
author_facet | Zhou, Si-ying Chen, Wei Yang, Su-jin Xu, Zi-han Hu, Jia-hua Zhang, He-da Zhong, Shan-liang Tang, Jin-hai |
author_sort | Zhou, Si-ying |
collection | PubMed |
description | Breast cancer (BCa) is one of the most frequently diagnosed cancers and leading cause of cancer deaths among females worldwide. Circular RNAs (circRNAs) are a new class of endogenous regulatory RNAs characterized by circular shape resulting from covalently closed continuous loops that are capable of regulating gene expression at transcription or post-transcription levels. With the unique structures, circRNAs are resistant to exonuclease RNase R and maintain stability more easily than linear RNAs. Recently, an increasing number of circRNAs are discovered and reported to show different expression in BCa and these dysregulated circRNAs were correlated with patients’ clinical characteristics and grade in the progression of BCa. CircRNAs participate in the bioprocesses of carcinogenesis of BCa, including cell proliferation, apoptosis, cell cycle, tumorigenesis, vascularization, cell invasion, migration as well as metastasis. Here we concentrated on biogenesis and function of circRNAs, summarized their implications in BCa and discussed their potential as diagnostic and therapeutic targets for BCa. |
format | Online Article Text |
id | pubmed-6591565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65915652019-06-27 The emerging role of circular RNAs in breast cancer Zhou, Si-ying Chen, Wei Yang, Su-jin Xu, Zi-han Hu, Jia-hua Zhang, He-da Zhong, Shan-liang Tang, Jin-hai Biosci Rep Review Articles Breast cancer (BCa) is one of the most frequently diagnosed cancers and leading cause of cancer deaths among females worldwide. Circular RNAs (circRNAs) are a new class of endogenous regulatory RNAs characterized by circular shape resulting from covalently closed continuous loops that are capable of regulating gene expression at transcription or post-transcription levels. With the unique structures, circRNAs are resistant to exonuclease RNase R and maintain stability more easily than linear RNAs. Recently, an increasing number of circRNAs are discovered and reported to show different expression in BCa and these dysregulated circRNAs were correlated with patients’ clinical characteristics and grade in the progression of BCa. CircRNAs participate in the bioprocesses of carcinogenesis of BCa, including cell proliferation, apoptosis, cell cycle, tumorigenesis, vascularization, cell invasion, migration as well as metastasis. Here we concentrated on biogenesis and function of circRNAs, summarized their implications in BCa and discussed their potential as diagnostic and therapeutic targets for BCa. Portland Press Ltd. 2019-06-25 /pmc/articles/PMC6591565/ /pubmed/31160488 http://dx.doi.org/10.1042/BSR20190621 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Articles Zhou, Si-ying Chen, Wei Yang, Su-jin Xu, Zi-han Hu, Jia-hua Zhang, He-da Zhong, Shan-liang Tang, Jin-hai The emerging role of circular RNAs in breast cancer |
title | The emerging role of circular RNAs in breast cancer |
title_full | The emerging role of circular RNAs in breast cancer |
title_fullStr | The emerging role of circular RNAs in breast cancer |
title_full_unstemmed | The emerging role of circular RNAs in breast cancer |
title_short | The emerging role of circular RNAs in breast cancer |
title_sort | emerging role of circular rnas in breast cancer |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591565/ https://www.ncbi.nlm.nih.gov/pubmed/31160488 http://dx.doi.org/10.1042/BSR20190621 |
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