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Leishmania Vaccines Entered in Clinical Trials: A Review of Literature
Leishmaniasis is considered as a zoonotic infection and neglected tropical disease. Leishmania treatment is not totally successful and imposes high expenditures, especially in developing countries. Since the natural infection leads to the robust immunity in most of the human cases, many bodies of re...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592111/ https://www.ncbi.nlm.nih.gov/pubmed/31360342 http://dx.doi.org/10.4103/ijpvm.IJPVM_116_18 |
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author | Moafi, Mohammad Rezvan, Hossein Sherkat, Roya Taleban, Roya |
author_facet | Moafi, Mohammad Rezvan, Hossein Sherkat, Roya Taleban, Roya |
author_sort | Moafi, Mohammad |
collection | PubMed |
description | Leishmaniasis is considered as a zoonotic infection and neglected tropical disease. Leishmania treatment is not totally successful and imposes high expenditures, especially in developing countries. Since the natural infection leads to the robust immunity in most of the human cases, many bodies of research have been focusing on Leishmania vaccines, being capable to control Leishmania infection. First generation vaccines (such as Leishmune(®) and CaniLeish(®)) have proved robust protective immunity in dogs. In human, recombinant vaccines, including Leish-F1 could confer some degrees of protective immunity against natural infection. Recently, ChAd63-KH DNA vaccine has been accomplished in providing prevention against Leishmania infection; however, this vaccine should be further evaluated in other clinical trials. |
format | Online Article Text |
id | pubmed-6592111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-65921112019-07-29 Leishmania Vaccines Entered in Clinical Trials: A Review of Literature Moafi, Mohammad Rezvan, Hossein Sherkat, Roya Taleban, Roya Int J Prev Med Review Article Leishmaniasis is considered as a zoonotic infection and neglected tropical disease. Leishmania treatment is not totally successful and imposes high expenditures, especially in developing countries. Since the natural infection leads to the robust immunity in most of the human cases, many bodies of research have been focusing on Leishmania vaccines, being capable to control Leishmania infection. First generation vaccines (such as Leishmune(®) and CaniLeish(®)) have proved robust protective immunity in dogs. In human, recombinant vaccines, including Leish-F1 could confer some degrees of protective immunity against natural infection. Recently, ChAd63-KH DNA vaccine has been accomplished in providing prevention against Leishmania infection; however, this vaccine should be further evaluated in other clinical trials. Wolters Kluwer - Medknow 2019-06-07 /pmc/articles/PMC6592111/ /pubmed/31360342 http://dx.doi.org/10.4103/ijpvm.IJPVM_116_18 Text en Copyright: © 2019 International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Moafi, Mohammad Rezvan, Hossein Sherkat, Roya Taleban, Roya Leishmania Vaccines Entered in Clinical Trials: A Review of Literature |
title | Leishmania Vaccines Entered in Clinical Trials: A Review of Literature |
title_full | Leishmania Vaccines Entered in Clinical Trials: A Review of Literature |
title_fullStr | Leishmania Vaccines Entered in Clinical Trials: A Review of Literature |
title_full_unstemmed | Leishmania Vaccines Entered in Clinical Trials: A Review of Literature |
title_short | Leishmania Vaccines Entered in Clinical Trials: A Review of Literature |
title_sort | leishmania vaccines entered in clinical trials: a review of literature |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592111/ https://www.ncbi.nlm.nih.gov/pubmed/31360342 http://dx.doi.org/10.4103/ijpvm.IJPVM_116_18 |
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