Cargando…

Combination Therapy of TGF-β Blockade and Commensal-derived Probiotics Provides Enhanced Antitumor Immune Response and Tumor Suppression

Galunisertib (Gal) is a transforming growth factor (TGF-β) blockade which is being investigated as a potential tumor immunotherapy candidate drug in clinical trials. However, primary or acquired resistance is often found in the recruited cancer patients, which limits its clinical application. Tumor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Linlin, Sheng, Jianyong, Wang, Mengli, Luo, Han, Zhu, Jun, Zhang, Bixiang, Liu, Zhi, Yang, Xiangliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592171/ https://www.ncbi.nlm.nih.gov/pubmed/31281535 http://dx.doi.org/10.7150/thno.35131

Ejemplares similares

Combining IL-2-based immunotherapy with commensal probiotics produces enhanced antitumor immune response and tumor clearance
por: Shi, Linlin, et al.
Publicado: (2020)

Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade
por: Greco, Rita, et al.
Publicado: (2020)

Blockade of Treg derived TGF-β abrogates suppression of effector T cell function within the tumor microenvironment
por: Budhu, Sadna, et al.
Publicado: (2013)

TGFβ: Signaling Blockade for Cancer Immunotherapy
por: Chen, Szu-Ying, et al.
Publicado: (2022)

Probiotics Lactobacillus reuteri Abrogates Immune Checkpoint Blockade-Associated Colitis by Inhibiting Group 3 Innate Lymphoid Cells
por: Wang, Tingting, et al.
Publicado: (2019)

Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells
por: Wu, Xian, et al.
Publicado: (2018)

Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma
por: Lucarini, Valeria, et al.
Publicado: (2022)

TGFβ/BMP immune signaling affects abundance and function of C. elegans gut commensals
por: Berg, Maureen, et al.
Publicado: (2019)

The abscopal effect of local radiotherapy is induced by TGFβ blockade
por: Diamond, Julie, et al.
Publicado: (2013)

A potential treatment of COVID-19 with TGF-β blockade
por: Chen, WanJun
Publicado: (2020)

Immune targeting of three independent suppressive pathways (TIGIT, PD-L1, TGFβ) provides significant antitumor efficacy in immune checkpoint resistant models
por: Franks, S. Elizabeth, et al.
Publicado: (2022)

Blockade of surface bound TGF-β abrogates Treg suppression of effector T cell function within the tumor microenvironment
por: Budhu, Sadna, et al.
Publicado: (2014)

Inhibition of TGF-β signaling with halofuginone can enhance the antitumor effect of irradiation in Lewis lung cancer
por: Lin, Runlong, et al.
Publicado: (2015)

The Many Faces of Enterococcus spp.—Commensal, Probiotic and Opportunistic Pathogen
por: Krawczyk, Beata, et al.
Publicado: (2021)

Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide
por: Chen, Xin, et al.
Publicado: (2014)

Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer
por: Huang, Huocong, et al.
Publicado: (2019)

Probiotics, their action modality and the use of multi-omics in metamorphosis of commensal microbiota into target-based probiotics
por: Idrees, Maryam, et al.
Publicado: (2022)

Translating the combination of TGFβ blockade and radiotherapy into clinical development in glioblastoma
por: Zhang, Mengxian, et al.
Publicado: (2012)

Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma
por: Han, Mengzhen, et al.
Publicado: (2020)

Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy
por: Groeneveldt, Christianne, et al.
Publicado: (2023)

Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis
por: Lecomte, Sara, et al.
Publicado: (2023)

Polyamine blockade promotes antitumor immunity
por: Hayes, Candace S, et al.
Publicado: (2014)

PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
por: Xu-Monette, Zijun Y., et al.
Publicado: (2017)

Role of Natural Killer and Dendritic Cell Crosstalk in Immunomodulation by Commensal Bacteria Probiotics
por: Rizzello, Valeria, et al.
Publicado: (2011)

Metabolic Interactions in the Gastrointestinal Tract (GIT): Host, Commensal, Probiotics, and Bacteriophage Influences
por: Vitetta, Luis, et al.
Publicado: (2015)

ST2 blockade mitigates peritoneal fibrosis induced by TGF‐β and high glucose
por: Kim, Yong Chul, et al.
Publicado: (2019)

Dual-responsive nanosystem based on TGF-β blockade and immunogenic chemotherapy for effective chemoimmunotherapy
por: Huang, Xiaoxian, et al.
Publicado: (2022)

Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease
por: Martín, Rebeca, et al.
Publicado: (2013)

Editorial: Next-Generation Probiotics: From Commensal Bacteria to Novel Drugs and Food Supplements
por: Langella, Philippe, et al.
Publicado: (2019)

Probiotics and Commensal Gut Microbiota as the Effective Alternative Therapy for Multiple Sclerosis Patients Treatment
por: Dziedzic, Angela, et al.
Publicado: (2022)

Characterization of TGFβ-associated molecular features and drug responses in gastrointestinal adenocarcinoma
por: Zhang, Qiaofeng, et al.
Publicado: (2021)

Anti-TGF-β Antibody Combined with Dendritic Cells Produce Antitumor Effects in Osteosarcoma
por: Kawano, Masanori, et al.
Publicado: (2012)

Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation
por: Shen, Yingying, et al.
Publicado: (2022)

Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia
por: Rivas, J.R., et al.
Publicado: (2021)

A micropeptide JunBP regulated by TGF-β promotes hepatocellular carcinoma metastasis
por: Zhang, Hongwei, et al.
Publicado: (2022)

Antitumor Effects of Baicalein and Its Mechanism via TGFβ Pathway in Cervical Cancer HeLa Cells
por: Yu, Gang, et al.
Publicado: (2021)

Regulatory role of suppressive motifs from commensal DNA
por: Bouladoux, N., et al.
Publicado: (2012)

Effects of Probiotic Supplementation on TGF-β1, TGF-β2, and IgA Levels in the Milk of Japanese Women: An Open-Label Pilot Study
por: Takahashi, Tomoki, et al.
Publicado: (2019)

Blockade of TGF-β 1 Signalling Inhibits Cardiac NADPH Oxidase Overactivity in Hypertensive Rats
por: Miguel-Carrasco, José Luis, et al.
Publicado: (2012)

TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
por: Mariathasan, Sanjeev, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dnbt3iovcm2k0d7ahk4a9thkln