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New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure
Sarcopenia is an age-related geriatric syndrome that is characterized by a progressive loss of muscle mass, strength and function. Chronic heart failure (CHF), the final stage of various cardiovascular diseases, may be closely correlated with the occurrence of sarcopenia. Accumulating evidence has d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Ivyspring International Publisher
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592172/ https://www.ncbi.nlm.nih.gov/pubmed/31281529 http://dx.doi.org/10.7150/thno.33000 |
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author | Yin, Jiayu Lu, Xiang Qian, Zhiyuan Xu, Weiting Zhou, Xiang |
author_facet | Yin, Jiayu Lu, Xiang Qian, Zhiyuan Xu, Weiting Zhou, Xiang |
author_sort | Yin, Jiayu |
collection | PubMed |
description | Sarcopenia is an age-related geriatric syndrome that is characterized by a progressive loss of muscle mass, strength and function. Chronic heart failure (CHF), the final stage of various cardiovascular diseases, may be closely correlated with the occurrence of sarcopenia. Accumulating evidence has demonstrated that CHF can promote the development of sarcopenia through multiple pathophysiological mechanisms, including malnutrition, inflammation, hormonal changes, oxidative stress, autophagy, and apoptosis. Additionally, CHF can aggravate the adverse outcomes associated with sarcopenia, including falls, osteoporosis, frailty, cachexia, hospitalization, and mortality. Sarcopenia and CHF are mutually interacting clinical syndromes. Patients with these two syndromes seem to endure a double burden, with no particularly effective way to hinder their progression. However, the combination of physical exercise, nutritional supplements, and drug therapy may counteract the development of these maladies. In this review, we will summarize the latest progress in the pathogenesis and treatment of sarcopenia in patients with CHF. |
format | Online Article Text |
id | pubmed-6592172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-65921722019-07-06 New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure Yin, Jiayu Lu, Xiang Qian, Zhiyuan Xu, Weiting Zhou, Xiang Theranostics Review Sarcopenia is an age-related geriatric syndrome that is characterized by a progressive loss of muscle mass, strength and function. Chronic heart failure (CHF), the final stage of various cardiovascular diseases, may be closely correlated with the occurrence of sarcopenia. Accumulating evidence has demonstrated that CHF can promote the development of sarcopenia through multiple pathophysiological mechanisms, including malnutrition, inflammation, hormonal changes, oxidative stress, autophagy, and apoptosis. Additionally, CHF can aggravate the adverse outcomes associated with sarcopenia, including falls, osteoporosis, frailty, cachexia, hospitalization, and mortality. Sarcopenia and CHF are mutually interacting clinical syndromes. Patients with these two syndromes seem to endure a double burden, with no particularly effective way to hinder their progression. However, the combination of physical exercise, nutritional supplements, and drug therapy may counteract the development of these maladies. In this review, we will summarize the latest progress in the pathogenesis and treatment of sarcopenia in patients with CHF. Ivyspring International Publisher 2019-05-31 /pmc/articles/PMC6592172/ /pubmed/31281529 http://dx.doi.org/10.7150/thno.33000 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Yin, Jiayu Lu, Xiang Qian, Zhiyuan Xu, Weiting Zhou, Xiang New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure |
title | New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure |
title_full | New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure |
title_fullStr | New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure |
title_full_unstemmed | New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure |
title_short | New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure |
title_sort | new insights into the pathogenesis and treatment of sarcopenia in chronic heart failure |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592172/ https://www.ncbi.nlm.nih.gov/pubmed/31281529 http://dx.doi.org/10.7150/thno.33000 |
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