Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands

In this study, we report a ligand-guided homology modeling approach allowing the analysis of relevant binding site residue conformations and the identification of two novel histamine H(3) receptor ligands with binding affinity in the nanomolar range. The newly developed method is based on exploiting...

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Detalles Bibliográficos
Autores principales: Schaller, David, Hagenow, Stefanie, Stark, Holger, Wolber, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592549/
https://www.ncbi.nlm.nih.gov/pubmed/31237914
http://dx.doi.org/10.1371/journal.pone.0218820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592549/
https://www.ncbi.nlm.nih.gov/pubmed/31237914
http://dx.doi.org/10.1371/journal.pone.0218820

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