Cargando…

Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a significant cancer of children resulting from the clonal proliferation of lymphoid precursors with arrested maturation. Although chemotherapeutic approaches have been achieving successful remission for the majority of cases of childhood ALL, development of res...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuttikrishnan, Shilpa, Siveen, Kodappully S., Prabhu, Kirti S., Khan, Abdul Quaiyoom, Ahmed, Eiman I., Akhtar, Sabah, Ali, Tayyiba A., Merhi, Maysaloun, Dermime, Said, Steinhoff, Martin, Uddin, Shahab
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593070/ https://www.ncbi.nlm.nih.gov/pubmed/31275848 http://dx.doi.org/10.3389/fonc.2019.00484

Ejemplares similares

Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines
por: Prabhu, Kirti S., et al.
Publicado: (2019)

Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products
por: Siveen, Kodappully S., et al.
Publicado: (2018)

Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells
por: Khan, Abdul Q., et al.
Publicado: (2018)

Corrigendum: Curcumin-mediated degradation of S-phase kinase protein 2 induces cytotoxic effects in human papillomavirus-positive and negative squamous carcinoma cells
por: Khan, Abdul Q., et al.
Publicado: (2023)

Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines
por: Prabhu, Kirti S., et al.
Publicado: (2018)

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling
por: Akhtar, Sabah, et al.
Publicado: (2019)

Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway
por: Khan, Abdul Q., et al.
Publicado: (2020)

Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway
por: Akhtar, Sabah, et al.
Publicado: (2022)

Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells
por: Prabhu, Kirti S., et al.
Publicado: (2017)

Evaluation of cationic channel TRPV2 as a novel biomarker and therapeutic target in Leukemia-Implications concerning the resolution of pulmonary inflammation
por: Siveen, Kodappully S., et al.
Publicado: (2019)

The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer
por: Siveen, Kodappully S., et al.
Publicado: (2019)

Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells
por: Iskandarani, Ahmad, et al.
Publicado: (2016)

Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species
por: Khan, Abdul Q., et al.
Publicado: (2020)

Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells
por: Prabhu, Kirti S., et al.
Publicado: (2020)

Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity
por: Relecom, Allan, et al.
Publicado: (2021)

Unleashing the immune response to NY-ESO-1 cancer testis antigen as a potential target for cancer immunotherapy
por: Raza, Afsheen, et al.
Publicado: (2020)

Editorial: Dynamic Biomarkers of Response to Anti-Immune Checkpoint Inhibitors in Cancer
por: Dermime, Said, et al.
Publicado: (2021)

Targeting acute myeloid leukemia stem cell signaling by natural products
por: Siveen, Kodappully Sivaraman, et al.
Publicado: (2017)

CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
por: Maalej, Karama Makni, et al.
Publicado: (2023)

Persistent anti-NY-ESO-1-specific T cells and expression of differential biomarkers in a patient with metastatic gastric cancer benefiting from combined radioimmunotherapy treatment: a case report
por: Merhi, Maysaloun, et al.
Publicado: (2020)

Dysregulated Phosphorylation of p53, Autophagy and Stemness Attributes the Mutant p53 Harboring Colon Cancer Cells Impaired Sensitivity to Oxaliplatin
por: Therachiyil, Lubna, et al.
Publicado: (2020)

Role of Epstein–Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target
por: Fernandes, Queenie, et al.
Publicado: (2018)

Potential therapeutic targets of Guggulsterone in cancer
por: Bhat, Ajaz A., et al.
Publicado: (2017)

TRPV2: A Cancer Biomarker and Potential Therapeutic Target
por: Siveen, Kodappully S., et al.
Publicado: (2020)

Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases
por: Khan, Abdul Q., et al.
Publicado: (2020)

Squamous Cell Carcinomas of the Head and Neck Cancer Response to Programmed Cell Death Protein-1 Targeting and Differential Expression of Immunological Markers: A Case Report
por: Merhi, Maysaloun, et al.
Publicado: (2018)

CAR-T Cell Therapies: An Overview of Clinical Studies Supporting Their Approved Use against Acute Lymphoblastic Leukemia and Large B-Cell Lymphomas
por: Ahmad, Aamir, et al.
Publicado: (2020)

Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3
por: Shailesh, Harshita, et al.
Publicado: (2021)

Cytokine-Mediated Dysregulation of Signaling Pathways in the Pathogenesis of Multiple Myeloma
por: Akhtar, Sabah, et al.
Publicado: (2020)

Protein Expression Profiling Identifies Key Proteins and Pathways Involved in Growth Inhibitory Effects Exerted by Guggulsterone in Human Colorectal Cancer Cells
por: Leo, Rari, et al.
Publicado: (2019)

In vitro Interleukin-7 treatment partially rescues MAIT cell dysfunction caused by SARS-CoV-2 infection
por: Hubrack, Satanay, et al.
Publicado: (2021)

Urine as a Main Effector in Urological Tissue Engineering—A Double-Edged Sword
por: Abbas, Tariq O., et al.
Publicado: (2020)

Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies
por: Khan, Abdul Q., et al.
Publicado: (2019)

Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer
por: Raza, Afsheen, et al.
Publicado: (2022)

Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
por: Bhat, Ajaz A., et al.
Publicado: (2021)

MCL-1 Inhibition Overcomes Anti-apoptotic Adaptation to Targeted Therapies in B-Cell Precursor Acute Lymphoblastic Leukemia
por: Manzano-Muñoz, Albert, et al.
Publicado: (2021)

Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines
por: Fernandes, Queenie, et al.
Publicado: (2022)

Phytochemicals in Cancer Prevention and Therapy
por: Pratheeshkumar, Poyil, et al.
Publicado: (2015)

The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance
por: Patil, Kalyani, et al.
Publicado: (2021)

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance
por: Bhat, Ajaz A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_00vmiha42r1qvuoh7rok0rnb1j