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Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells
The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis. Importantly, the nexus of epithelial–immune responses at mucosal surfaces is d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593103/ https://www.ncbi.nlm.nih.gov/pubmed/31275305 http://dx.doi.org/10.3389/fimmu.2019.01281 |
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author | Kurashima, Yosuke Tokuhara, Daisuke Kamioka, Mariko Inagaki, Yutaka Kiyono, Hiroshi |
author_facet | Kurashima, Yosuke Tokuhara, Daisuke Kamioka, Mariko Inagaki, Yutaka Kiyono, Hiroshi |
author_sort | Kurashima, Yosuke |
collection | PubMed |
description | The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis. Importantly, the nexus of epithelial–immune responses at mucosal surfaces is dexterously modulated by intrinsic stromal–mesenchymal cells. First, organogenesis of lymphoid tissues, including Peyer's patches, requires dynamic interplay between lymphoid cells and stromal cells, which have become known as “lymphoid organizers.” Second, correct spatiotemporal interaction between these cell populations is essential to generate the infrastructure for gut immune responses. Moreover, immune cells at the intestinal barrier are functionally modulated by stromal cells; one such example is the stromal cell–mediated differentiation of innate immune cells, including innate lymphoid cells and mast cells. Ultimately, mucosal stromal cells orchestrate the destinations of epithelial and immune cells to maintain intestinal immune homeostasis. |
format | Online Article Text |
id | pubmed-6593103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65931032019-07-03 Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells Kurashima, Yosuke Tokuhara, Daisuke Kamioka, Mariko Inagaki, Yutaka Kiyono, Hiroshi Front Immunol Immunology The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis. Importantly, the nexus of epithelial–immune responses at mucosal surfaces is dexterously modulated by intrinsic stromal–mesenchymal cells. First, organogenesis of lymphoid tissues, including Peyer's patches, requires dynamic interplay between lymphoid cells and stromal cells, which have become known as “lymphoid organizers.” Second, correct spatiotemporal interaction between these cell populations is essential to generate the infrastructure for gut immune responses. Moreover, immune cells at the intestinal barrier are functionally modulated by stromal cells; one such example is the stromal cell–mediated differentiation of innate immune cells, including innate lymphoid cells and mast cells. Ultimately, mucosal stromal cells orchestrate the destinations of epithelial and immune cells to maintain intestinal immune homeostasis. Frontiers Media S.A. 2019-06-19 /pmc/articles/PMC6593103/ /pubmed/31275305 http://dx.doi.org/10.3389/fimmu.2019.01281 Text en Copyright © 2019 Kurashima, Tokuhara, Kamioka, Inagaki and Kiyono. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Kurashima, Yosuke Tokuhara, Daisuke Kamioka, Mariko Inagaki, Yutaka Kiyono, Hiroshi Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells |
title | Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells |
title_full | Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells |
title_fullStr | Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells |
title_full_unstemmed | Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells |
title_short | Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells |
title_sort | intrinsic control of surface immune and epithelial homeostasis by tissue-resident gut stromal cells |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593103/ https://www.ncbi.nlm.nih.gov/pubmed/31275305 http://dx.doi.org/10.3389/fimmu.2019.01281 |
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