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Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells

The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis. Importantly, the nexus of epithelial–immune responses at mucosal surfaces is d...

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Autores principales: Kurashima, Yosuke, Tokuhara, Daisuke, Kamioka, Mariko, Inagaki, Yutaka, Kiyono, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593103/
https://www.ncbi.nlm.nih.gov/pubmed/31275305
http://dx.doi.org/10.3389/fimmu.2019.01281
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author Kurashima, Yosuke
Tokuhara, Daisuke
Kamioka, Mariko
Inagaki, Yutaka
Kiyono, Hiroshi
author_facet Kurashima, Yosuke
Tokuhara, Daisuke
Kamioka, Mariko
Inagaki, Yutaka
Kiyono, Hiroshi
author_sort Kurashima, Yosuke
collection PubMed
description The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis. Importantly, the nexus of epithelial–immune responses at mucosal surfaces is dexterously modulated by intrinsic stromal–mesenchymal cells. First, organogenesis of lymphoid tissues, including Peyer's patches, requires dynamic interplay between lymphoid cells and stromal cells, which have become known as “lymphoid organizers.” Second, correct spatiotemporal interaction between these cell populations is essential to generate the infrastructure for gut immune responses. Moreover, immune cells at the intestinal barrier are functionally modulated by stromal cells; one such example is the stromal cell–mediated differentiation of innate immune cells, including innate lymphoid cells and mast cells. Ultimately, mucosal stromal cells orchestrate the destinations of epithelial and immune cells to maintain intestinal immune homeostasis.
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spelling pubmed-65931032019-07-03 Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells Kurashima, Yosuke Tokuhara, Daisuke Kamioka, Mariko Inagaki, Yutaka Kiyono, Hiroshi Front Immunol Immunology The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis. Importantly, the nexus of epithelial–immune responses at mucosal surfaces is dexterously modulated by intrinsic stromal–mesenchymal cells. First, organogenesis of lymphoid tissues, including Peyer's patches, requires dynamic interplay between lymphoid cells and stromal cells, which have become known as “lymphoid organizers.” Second, correct spatiotemporal interaction between these cell populations is essential to generate the infrastructure for gut immune responses. Moreover, immune cells at the intestinal barrier are functionally modulated by stromal cells; one such example is the stromal cell–mediated differentiation of innate immune cells, including innate lymphoid cells and mast cells. Ultimately, mucosal stromal cells orchestrate the destinations of epithelial and immune cells to maintain intestinal immune homeostasis. Frontiers Media S.A. 2019-06-19 /pmc/articles/PMC6593103/ /pubmed/31275305 http://dx.doi.org/10.3389/fimmu.2019.01281 Text en Copyright © 2019 Kurashima, Tokuhara, Kamioka, Inagaki and Kiyono. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kurashima, Yosuke
Tokuhara, Daisuke
Kamioka, Mariko
Inagaki, Yutaka
Kiyono, Hiroshi
Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells
title Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells
title_full Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells
title_fullStr Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells
title_full_unstemmed Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells
title_short Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells
title_sort intrinsic control of surface immune and epithelial homeostasis by tissue-resident gut stromal cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593103/
https://www.ncbi.nlm.nih.gov/pubmed/31275305
http://dx.doi.org/10.3389/fimmu.2019.01281
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