Cargando…

Complex Formation between VEGFR2 and the β(2)-Adrenoceptor

Vascular endothelial growth factor (VEGF) is an important mediator of endothelial cell proliferation and angiogenesis via its receptor VEGFR2. A common tumor associated with elevated VEGFR2 signaling is infantile hemangioma that is caused by a rapid proliferation of vascular endothelial cells. The c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kilpatrick, Laura E., Alcobia, Diana C., White, Carl W., Peach, Chloe J., Glenn, Jackie R., Zimmerman, Kris, Kondrashov, Alexander, Pfleger, Kevin D.G., Ohana, Rachel Friedman, Robers, Matthew B., Wood, Keith V., Sloan, Erica K., Woolard, Jeanette, Hill, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593180/ https://www.ncbi.nlm.nih.gov/pubmed/30956148 http://dx.doi.org/10.1016/j.chembiol.2019.02.014

Ejemplares similares

Real-Time Ligand Binding of Fluorescent VEGF-A Isoforms that Discriminate between VEGFR2 and NRP1 in Living Cells
por: Peach, Chloe J., et al.
Publicado: (2018)

Real-time analysis of the binding of fluorescent VEGF(165)a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes
por: Kilpatrick, Laura E., et al.
Publicado: (2017)

Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2
por: Peach, Chloe J., et al.
Publicado: (2018)

Comparison of the ligand‐binding properties of fluorescent VEGF‐A isoforms to VEGF receptor 2 in living cells and membrane preparations using NanoBRET
por: Peach, Chloe J., et al.
Publicado: (2019)

Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET
por: Alcobia, Diana C., et al.
Publicado: (2018)

Involvement of β‐adrenoceptors in the cardiovascular responses induced by selective adenosine A(2A) and A(2B) receptor agonists
por: Wragg, Edward S., et al.
Publicado: (2022)

A monoclonal antibody raised against a thermo-stabilised β(1)-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β(1)-adrenoceptors expressed in stable cell lines
por: Soave, Mark, et al.
Publicado: (2018)

Effects of receptor tyrosine kinase inhibitors on VEGF(165)a- and VEGF(165)b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2
por: Carter, Joanne J, et al.
Publicado: (2015)

Novel selective β(1)-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease
por: Baker, Jillian G., et al.
Publicado: (2017)

Identification and Profiling of Novel α(1A)-Adrenoceptor-CXC Chemokine Receptor 2 Heteromer
por: Mustafa, Sanam, et al.
Publicado: (2012)

Use of a new proximity assay (NanoBRET) to investigate the ligand‐binding characteristics of three fluorescent ligands to the human β (1)‐adrenoceptor expressed in HEK‐293 cells
por: Soave, Mark, et al.
Publicado: (2016)

Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels
por: Goulding, Joëlle, et al.
Publicado: (2021)

The signaling and selectivity of α‐adrenoceptor agonists for the human α2A, α2B and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors
por: Proudman, Richard G. W., et al.
Publicado: (2022)

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion
por: Creed, Sarah J., et al.
Publicado: (2015)

The presence of β(2)-adrenoceptors sensitizes α(2A)-adrenoceptors to desensitization after chronic epinephrine treatment
por: Bawa-Khalfe, Tasneem, et al.
Publicado: (2007)

β-Adrenoceptor-mediated Relaxation of Urinary Bladder Muscle in β(2)-Adrenoceptor Knockout Mice
por: Propping, Stefan, et al.
Publicado: (2016)

The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors
por: Proudman, Richard G.W., et al.
Publicado: (2022)

β(2)‐Adrenoceptor agonist activity of higenamine
por: Hudzik, Thomas J., et al.
Publicado: (2021)

How Carvedilol activates β(2)-adrenoceptors
por: Benkel, Tobias, et al.
Publicado: (2022)

Utilizing a Simple Method for Stoichiometric Protein Labeling to Quantify Antibody Blockade
por: Friedman Ohana, Rachel, et al.
Publicado: (2019)

Alpha-2 adrenoceptor agonists and sepsis: improved survival?
por: Quintin, Luc
Publicado: (2010)

Paradoxical bronchoconstriction caused by β(2)-adrenoceptor agonists
por: Ayed, Khadija, et al.
Publicado: (2020)

How carvedilol does not activate β(2)-adrenoceptors
por: Lefkowitz, Robert J., et al.
Publicado: (2023)

A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding
por: White, Carl W., et al.
Publicado: (2020)

TBX1 Represses Vegfr2 Gene Expression and Enhances the Cardiac Fate of VEGFR2+ Cells
por: Lania, Gabriella, et al.
Publicado: (2015)

VEGFR-2 reduces while combined VEGFR-2 and -3 signaling increases inflammation in apical periodontitis
por: Virtej, Anca, et al.
Publicado: (2016)

The Role of Adrenoceptors in the Retina
por: Ruan, Yue, et al.
Publicado: (2020)

Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
por: Hwang, Jun-Eul, et al.
Publicado: (2013)

Distinct transcriptional responses of lymphatic endothelial cells to VEGFR-3 and VEGFR-2 stimulation
por: Dieterich, Lothar C., et al.
Publicado: (2017)

Diagnostic Value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline Mammary Carcinoma
por: Nascimento, Catarina, et al.
Publicado: (2021)

VEGFR2 alteration in Alzheimer’s disease
por: Cho, Sun-Jung, et al.
Publicado: (2017)

Structure and Function of an Irreversible Agonist-β(2) Adrenoceptor complex
por: Rosenbaum, Daniel M., et al.
Publicado: (2011)

Increased Beta2-Adrenoceptors in Doxorubicin-Induced Cardiomyopathy in Rat
por: Merlet, Nolwenn, et al.
Publicado: (2013)

Functional desensitization of the β(2) adrenoceptor is not dependent on agonist efficacy
por: Rosethorne, Elizabeth M, et al.
Publicado: (2015)

A Selective Pharmacophore Model for β(2)-Adrenoceptor Agonists
por: Xing, Rui-Juan, et al.
Publicado: (2009)

α (2)-Adrenoceptors: Challenges and Opportunities—Enlightenment from the Kidney
por: Pettinger, William A., et al.
Publicado: (2020)

Reply to: How carvedilol does not activate β(2)-adrenoceptors
por: Kostenis, Evi, et al.
Publicado: (2023)

Altered β(1−3)-adrenoceptor influence on α(2)-adrenoceptor-mediated control of catecholamine release and vascular tension in hypertensive rats
por: Berg, Torill
Publicado: (2015)

Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma
por: Jinnin, Masatoshi, et al.
Publicado: (2008)

VEGF-dependent tumor angiogenesis requires the inverse and reciprocal regulation of VEGFR1 and VEGFR2
por: Zhang, Zhaocheng, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_3dn95u65mij6k7ivbqij93scgj