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Disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy

BACKGROUND: Structural connectivity is a promising methodology to detect patterns of neural network dysfunction in neurodegenerative diseases. This approach has not been tested in progressive supranuclear palsy (PSP). OBJECTIVES: The aim of this study is reconstructing the structural connectome to c...

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Autores principales: Abos, Alexandra, Segura, Barbara, Baggio, Hugo C., Campabadal, Anna, Uribe, Carme, Garrido, Alicia, Camara, Ana, Muñoz, Esteban, Valldeoriola, Francesc, Marti, Maria Jose, Junque, Carme, Compta, Yaroslau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593210/
https://www.ncbi.nlm.nih.gov/pubmed/31229940
http://dx.doi.org/10.1016/j.nicl.2019.101899
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author Abos, Alexandra
Segura, Barbara
Baggio, Hugo C.
Campabadal, Anna
Uribe, Carme
Garrido, Alicia
Camara, Ana
Muñoz, Esteban
Valldeoriola, Francesc
Marti, Maria Jose
Junque, Carme
Compta, Yaroslau
author_facet Abos, Alexandra
Segura, Barbara
Baggio, Hugo C.
Campabadal, Anna
Uribe, Carme
Garrido, Alicia
Camara, Ana
Muñoz, Esteban
Valldeoriola, Francesc
Marti, Maria Jose
Junque, Carme
Compta, Yaroslau
author_sort Abos, Alexandra
collection PubMed
description BACKGROUND: Structural connectivity is a promising methodology to detect patterns of neural network dysfunction in neurodegenerative diseases. This approach has not been tested in progressive supranuclear palsy (PSP). OBJECTIVES: The aim of this study is reconstructing the structural connectome to characterize and detect the pathways of degeneration in PSP patients compared with healthy controls and their correlation with clinical features. The second objective is to assess the potential of structural connectivity measures to distinguish between PSP patients and healthy controls at the single-subject level. METHODS: Twenty healthy controls and 19 PSP patients underwent diffusion-weighted MRI with a 3T scanner. Structural connectivity, represented by number of streamlines, was derived from probabilistic tractography. Global and local network metrics were calculated based on graph theory. RESULTS: Reduced numbers of streamlines were predominantly found in connections between frontal areas and deep gray matter (DGM) structures in PSP compared with controls. Significant changes in structural connectivity correlated with clinical features in PSP patients. An abnormal small-world architecture was detected in the subnetwork comprising the frontal lobe and DGM structures in PSP patients. The classification procedure achieved an overall accuracy of 82.23% with 94.74% sensitivity and 70% specificity. CONCLUSION: Our findings suggest that modelling the brain as a structural connectome is a useful method to detect changes in the organization and topology of white matter tracts in PSP patients. Secondly, measures of structural connectivity have the potential to correctly discriminate between PSP patients and healthy controls.
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spelling pubmed-65932102019-07-09 Disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy Abos, Alexandra Segura, Barbara Baggio, Hugo C. Campabadal, Anna Uribe, Carme Garrido, Alicia Camara, Ana Muñoz, Esteban Valldeoriola, Francesc Marti, Maria Jose Junque, Carme Compta, Yaroslau Neuroimage Clin Regular Article BACKGROUND: Structural connectivity is a promising methodology to detect patterns of neural network dysfunction in neurodegenerative diseases. This approach has not been tested in progressive supranuclear palsy (PSP). OBJECTIVES: The aim of this study is reconstructing the structural connectome to characterize and detect the pathways of degeneration in PSP patients compared with healthy controls and their correlation with clinical features. The second objective is to assess the potential of structural connectivity measures to distinguish between PSP patients and healthy controls at the single-subject level. METHODS: Twenty healthy controls and 19 PSP patients underwent diffusion-weighted MRI with a 3T scanner. Structural connectivity, represented by number of streamlines, was derived from probabilistic tractography. Global and local network metrics were calculated based on graph theory. RESULTS: Reduced numbers of streamlines were predominantly found in connections between frontal areas and deep gray matter (DGM) structures in PSP compared with controls. Significant changes in structural connectivity correlated with clinical features in PSP patients. An abnormal small-world architecture was detected in the subnetwork comprising the frontal lobe and DGM structures in PSP patients. The classification procedure achieved an overall accuracy of 82.23% with 94.74% sensitivity and 70% specificity. CONCLUSION: Our findings suggest that modelling the brain as a structural connectome is a useful method to detect changes in the organization and topology of white matter tracts in PSP patients. Secondly, measures of structural connectivity have the potential to correctly discriminate between PSP patients and healthy controls. Elsevier 2019-06-15 /pmc/articles/PMC6593210/ /pubmed/31229940 http://dx.doi.org/10.1016/j.nicl.2019.101899 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Abos, Alexandra
Segura, Barbara
Baggio, Hugo C.
Campabadal, Anna
Uribe, Carme
Garrido, Alicia
Camara, Ana
Muñoz, Esteban
Valldeoriola, Francesc
Marti, Maria Jose
Junque, Carme
Compta, Yaroslau
Disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy
title Disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy
title_full Disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy
title_fullStr Disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy
title_full_unstemmed Disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy
title_short Disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy
title_sort disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593210/
https://www.ncbi.nlm.nih.gov/pubmed/31229940
http://dx.doi.org/10.1016/j.nicl.2019.101899
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