The K(Ca)2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts

Background and Purpose: Prolongation of cardiac action potentials is considered antiarrhythmic in the atria but can be proarrhythmic in ventricles if the current carried by Kv11.1-channels (I(Kr)) is inhibited. The current mediated by K(Ca)2-channels, I(KCa), is considered a promising new target for...

Descripción completa

Detalles Bibliográficos
Autores principales: Kirchhoff, Jeppe Egedal, Skarsfeldt, Mark Alexander, Muthukumarasamy, Kalai Mangai, Simó-Vicens, Rafel, Bomholtz, Sofia Hammami, Abildgaard, Lea, Jespersen, Thomas, Sørensen, Ulrik S., Grunnet, Morten, Bentzen, Bo Hjorth, Diness, Jonas Goldin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593233/
https://www.ncbi.nlm.nih.gov/pubmed/31275147
http://dx.doi.org/10.3389/fphar.2019.00668

Ejemplares similares

Ejemplares similares