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Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking

Microscopy and medical imaging are related in their exploitation of electromagnetic waves, but were developed to satisfy differing needs, namely to observe small objects or to look inside subjects/objects, respectively. Together, these techniques can help elucidate complex biological processes and b...

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Detalles Bibliográficos
Autores principales: Volpe, Alessia, Kurtys, Ewelina, Fruhwirth, Gilbert O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593261/
https://www.ncbi.nlm.nih.gov/pubmed/29960079
http://dx.doi.org/10.1016/j.biocel.2018.06.008
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author Volpe, Alessia
Kurtys, Ewelina
Fruhwirth, Gilbert O.
author_facet Volpe, Alessia
Kurtys, Ewelina
Fruhwirth, Gilbert O.
author_sort Volpe, Alessia
collection PubMed
description Microscopy and medical imaging are related in their exploitation of electromagnetic waves, but were developed to satisfy differing needs, namely to observe small objects or to look inside subjects/objects, respectively. Together, these techniques can help elucidate complex biological processes and better understand health and disease. A current major challenge is to delineate mechanisms governing cell migration and tissue invasion in organismal development, the immune system and in human diseases such as cancer where the spatiotemporal tracking of small cell numbers in live animal models is extremely challenging. Multi-modal multi-scale in vivo cell tracking integrates medical and optical imaging. Fuelled by basic research in cancer biology and cell-based therapeutics, it has been enabled by technological advances providing enhanced resolution, sensitivity and multiplexing capabilities. Here, we review which imaging modalities have been successfully used for in vivo cell tracking and how this challenging task has benefitted from combining macroscopic with microscopic techniques.
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spelling pubmed-65932612019-07-10 Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking Volpe, Alessia Kurtys, Ewelina Fruhwirth, Gilbert O. Int J Biochem Cell Biol Article Microscopy and medical imaging are related in their exploitation of electromagnetic waves, but were developed to satisfy differing needs, namely to observe small objects or to look inside subjects/objects, respectively. Together, these techniques can help elucidate complex biological processes and better understand health and disease. A current major challenge is to delineate mechanisms governing cell migration and tissue invasion in organismal development, the immune system and in human diseases such as cancer where the spatiotemporal tracking of small cell numbers in live animal models is extremely challenging. Multi-modal multi-scale in vivo cell tracking integrates medical and optical imaging. Fuelled by basic research in cancer biology and cell-based therapeutics, it has been enabled by technological advances providing enhanced resolution, sensitivity and multiplexing capabilities. Here, we review which imaging modalities have been successfully used for in vivo cell tracking and how this challenging task has benefitted from combining macroscopic with microscopic techniques. Elsevier 2018-09 /pmc/articles/PMC6593261/ /pubmed/29960079 http://dx.doi.org/10.1016/j.biocel.2018.06.008 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Volpe, Alessia
Kurtys, Ewelina
Fruhwirth, Gilbert O.
Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking
title Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking
title_full Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking
title_fullStr Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking
title_full_unstemmed Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking
title_short Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking
title_sort cousins at work: how combining medical with optical imaging enhances in vivo cell tracking
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593261/
https://www.ncbi.nlm.nih.gov/pubmed/29960079
http://dx.doi.org/10.1016/j.biocel.2018.06.008
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