Annotating Transcriptional Effects of Genetic Variants in Disease‐Relevant Tissue: Transcriptome‐Wide Allelic Imbalance in Osteoarthritic Cartilage

OBJECTIVE: Multiple single‐nucleotide polymorphisms (SNPs) conferring susceptibility to osteoarthritis (OA) mark imbalanced expression of positional genes in articular cartilage, reflected by unequally expressed alleles among heterozygotes (allelic imbalance [AI]). We undertook this study to explore...

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Detalles Bibliográficos
Autores principales: den Hollander, Wouter, Pulyakhina, Irina, Boer, Cindy, Bomer, Nils, van der Breggen, Ruud, Arindrarto, Wibowo, Couthino de Almeida, Rodrigo, Lakenberg, Nico, Sentner, Thom, Laros, Jeroen F. J., ‘t Hoen, Peter A. C., Slagboom, Eline P. E., Nelissen, Rob G. H. H., van Meurs, Joyce, Ramos, Yolande F. M., Meulenbelt, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Osteoarthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593438/
https://www.ncbi.nlm.nih.gov/pubmed/30298554
http://dx.doi.org/10.1002/art.40748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593438/
https://www.ncbi.nlm.nih.gov/pubmed/30298554
http://dx.doi.org/10.1002/art.40748

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