Cargando…

Annotating Transcriptional Effects of Genetic Variants in Disease‐Relevant Tissue: Transcriptome‐Wide Allelic Imbalance in Osteoarthritic Cartilage

OBJECTIVE: Multiple single‐nucleotide polymorphisms (SNPs) conferring susceptibility to osteoarthritis (OA) mark imbalanced expression of positional genes in articular cartilage, reflected by unequally expressed alleles among heterozygotes (allelic imbalance [AI]). We undertook this study to explore...

Descripción completa

Detalles Bibliográficos
Autores principales:	den Hollander, Wouter, Pulyakhina, Irina, Boer, Cindy, Bomer, Nils, van der Breggen, Ruud, Arindrarto, Wibowo, Couthino de Almeida, Rodrigo, Lakenberg, Nico, Sentner, Thom, Laros, Jeroen F. J., ‘t Hoen, Peter A. C., Slagboom, Eline P. E., Nelissen, Rob G. H. H., van Meurs, Joyce, Ramos, Yolande F. M., Meulenbelt, Ingrid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Osteoarthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593438/ https://www.ncbi.nlm.nih.gov/pubmed/30298554 http://dx.doi.org/10.1002/art.40748

Ejemplares similares

Elucidating Epigenetic Regulation by Identifying Functional cis‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage
por: van Hoolwerff, Marcella, et al.
Publicado: (2020)

RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage
por: Coutinho de Almeida, Rodrigo, et al.
Publicado: (2019)

RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets
por: Tuerlings, Margo, et al.
Publicado: (2021)

MRI-based hip cartilage measures in osteoarthritic and non-osteoarthritic individuals: a systematic review
por: Aguilar, Hector N, et al.
Publicado: (2017)

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice
por: Bomer, Nils, et al.
Publicado: (2016)

Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage
por: Ali, Shabana Amanda, et al.
Publicado: (2016)

Noninvasive Mechanical Joint Loading as an Alternative Model for Osteoarthritic Pain
por: ter Heegde, Freija, et al.
Publicado: (2019)

Genes Involved in the Osteoarthritis Process Identified through Genome Wide Expression Analysis in Articular Cartilage; the RAAK Study
por: Ramos, Yolande F. M., et al.
Publicado: (2014)

Vitamin K antagonist anticoagulant usage is associated with increased incidence and progression of osteoarthritis
por: Boer, Cindy G, et al.
Publicado: (2021)

Transcriptome-Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes
por: Tew, Simon R, et al.
Publicado: (2014)

Matriptase Induction of Metalloproteinase‐Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms
por: Wilkinson, David J., et al.
Publicado: (2017)

Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation
por: Imagawa, Kei, et al.
Publicado: (2014)

Translation of clinical problems in osteoarthritis into pathophysiological research goals
por: van der Kraan, Peter M, et al.
Publicado: (2016)

Nociceptive Sensitizers Are Regulated in Damaged Joint Tissues, Including Articular Cartilage, When Osteoarthritic Mice Display Pain Behavior
por: Driscoll, Clare, et al.
Publicado: (2016)

NFAT1 protects articular cartilage against osteoarthritic degradation by directly regulating transcription of specific anabolic and catabolic genes
por: Zhang, M., et al.
Publicado: (2019)

Suppressive Effects of Insulin on Tumor Necrosis Factor–Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus
por: Hamada, Daisuke, et al.
Publicado: (2016)

Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene
por: Boer, Cindy Germaine, et al.
Publicado: (2021)

Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies
por: Rodriguez-Fontenla, Cristina, et al.
Publicado: (2014)

Risk Assessment for Hip and Knee Osteoarthritis Using Polygenic Risk Scores
por: Sedaghati‐Khayat, Bahar, et al.
Publicado: (2022)

Allelic expression imbalance in articular cartilage and subchondral bone refined genome-wide association signals in osteoarthritis
por: Coutinho de Almeida, Rodrigo, et al.
Publicado: (2022)

Defining an International Standard Set of Outcome Measures for Patients With Hip or Knee Osteoarthritis: Consensus of the International Consortium for Health Outcomes Measurement Hip and Knee Osteoarthritis Working Group
por: Rolfson, Ola, et al.
Publicado: (2016)

A Genome‐Wide Association Study Meta‐Analysis of Alpha Angle Suggests Cam‐Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults
por: Faber, Benjamin G., et al.
Publicado: (2023)

Economic Evaluation of the Dr. Bart Application in Individuals With Knee and/or Hip Osteoarthritis
por: Pelle, Tim, et al.
Publicado: (2022)

Decreased Pain and Improved Dynamic Knee Instability Mediate the Beneficial Effect of Wearing a Soft Knee Brace on Activity Limitations in Patients With Knee Osteoarthritis
por: Cudejko, Tomasz, et al.
Publicado: (2019)

Walking Disabilities in Association With Tenosynovitis at the Metatarsophalangeal Joints: A Longitudinal Magnetic Resonance Imaging Study in Early Arthritis
por: Dakkak, Yousra J., et al.
Publicado: (2022)

10-Year natural course of early hip osteoarthritis in middle-aged persons with hip pain: a CHECK study
por: van Berkel, Annemaria C., et al.
Publicado: (2021)

Towards secondary prevention of early knee osteoarthritis
por: Mahmoudian, Armaghan, et al.
Publicado: (2018)

Mechanisms of action of therapeutic exercise for knee and hip OA remain a black box phenomenon: an individual patient data mediation study with the OA Trial Bank
por: Runhaar, Jos, et al.
Publicado: (2023)

Incidence and Prevalence of Knee Osteoarthritis Using Codified and Narrative Data From Electronic Health Records: A Population‐Based Study
por: Arslan, Ilgin G., et al.
Publicado: (2022)

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis
por: Bomer, Nils, et al.
Publicado: (2015)

Surgical denervation as a treatment strategy for pain in hand osteoarthritis: a systematic literature review
por: van der Meulen, Coen, et al.
Publicado: (2023)

Quality indicators for knee and hip osteoarthritis care: a systematic review
por: Arslan, Ilgin G, et al.
Publicado: (2021)

Reliability of Assessing Hand Osteoarthritis on Digital Photographs and Associations With Radiographic and Clinical Findings
por: Marshall, Michelle, et al.
Publicado: (2014)

Do Smoking and Socioeconomic Factors Influence Imaging Outcomes in Axial Spondyloarthritis? Five‐Year Data From the DESIR Cohort
por: Nikiphorou, Elena, et al.
Publicado: (2020)

Two‐Year Changes in Magnetic Resonance Imaging Features and Pain in Thumb Base Osteoarthritis
por: van Beest, Sjoerd, et al.
Publicado: (2021)

Hand osteoarthritis is associated with limitations in paid and unpaid work participation and related societal costs: the HOSTAS cohort
por: Terpstra, Sietse E S, et al.
Publicado: (2022)

Men and Women's Occupational Activities and the Risk of Developing Osteoarthritis of the Knee, Hip, or Hands: A Systematic Review and Recommendations for Future Research
por: Gignac, Monique A. M., et al.
Publicado: (2020)

No Added Value of Duloxetine in Patients With Chronic Pain due to Hip or Knee Osteoarthritis: A Cluster‐Randomized Trial
por: van den Driest, Jacoline J., et al.
Publicado: (2022)

Baseline clinical characteristics of predicted structural and pain progressors in the IMI-APPROACH knee OA cohort
por: van Helvoort, Eefje Martine, et al.
Publicado: (2021)

Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative
por: Camacho-Encina, María, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lo04qcgc8b7v6c2r9g5m5kg9vf