Accumulation of prion protein in the vagus nerve in creutzfeldt–jakob disease

Disease‐associated proteins are thought to propagate along neuronal processes in neurodegenerative diseases. To detect disease‐associated prion protein (PrP(Sc)) in the vagus nerve in different forms and molecular subtypes of Creutzfeldt–Jakob disease (CJD), we applied 3 different anti‐PrP antibodie...

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Autores principales: Kresl, Philip, Rahimi, Jasmin, Gelpi, Ellen, Aldecoa, Iban, Ricken, Gerda, Danics, Krisztina, Keller, Eva, Kovacs, Gabor G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593447/
https://www.ncbi.nlm.nih.gov/pubmed/30801763
http://dx.doi.org/10.1002/ana.25451
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author Kresl, Philip
Rahimi, Jasmin
Gelpi, Ellen
Aldecoa, Iban
Ricken, Gerda
Danics, Krisztina
Keller, Eva
Kovacs, Gabor G.
author_facet Kresl, Philip
Rahimi, Jasmin
Gelpi, Ellen
Aldecoa, Iban
Ricken, Gerda
Danics, Krisztina
Keller, Eva
Kovacs, Gabor G.
author_sort Kresl, Philip
collection PubMed
description Disease‐associated proteins are thought to propagate along neuronal processes in neurodegenerative diseases. To detect disease‐associated prion protein (PrP(Sc)) in the vagus nerve in different forms and molecular subtypes of Creutzfeldt–Jakob disease (CJD), we applied 3 different anti‐PrP antibodies. We screened the vagus nerve in 162 sporadic and 30 genetic CJD cases. Four of 31 VV‐2 type sporadic CJD and 7 of 30 genetic CJD cases showed vagal PrP(Sc) immunodeposits with distinct morphology. Thus, PrP(Sc) in CJD affects the vagus nerve analogously to α‐synuclein in Parkinson disease. The morphologically diverse deposition of PrP(Sc) in genetic and sporadic CJD argues against uniform mechanisms of propagation of PrP(Sc). Ann Neurol 2019;85:782–787
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spelling pubmed-65934472019-07-10 Accumulation of prion protein in the vagus nerve in creutzfeldt–jakob disease Kresl, Philip Rahimi, Jasmin Gelpi, Ellen Aldecoa, Iban Ricken, Gerda Danics, Krisztina Keller, Eva Kovacs, Gabor G. Ann Neurol Brief Communications Disease‐associated proteins are thought to propagate along neuronal processes in neurodegenerative diseases. To detect disease‐associated prion protein (PrP(Sc)) in the vagus nerve in different forms and molecular subtypes of Creutzfeldt–Jakob disease (CJD), we applied 3 different anti‐PrP antibodies. We screened the vagus nerve in 162 sporadic and 30 genetic CJD cases. Four of 31 VV‐2 type sporadic CJD and 7 of 30 genetic CJD cases showed vagal PrP(Sc) immunodeposits with distinct morphology. Thus, PrP(Sc) in CJD affects the vagus nerve analogously to α‐synuclein in Parkinson disease. The morphologically diverse deposition of PrP(Sc) in genetic and sporadic CJD argues against uniform mechanisms of propagation of PrP(Sc). Ann Neurol 2019;85:782–787 John Wiley & Sons, Inc. 2019-03-11 2019-05 /pmc/articles/PMC6593447/ /pubmed/30801763 http://dx.doi.org/10.1002/ana.25451 Text en © 2019 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Brief Communications
Kresl, Philip
Rahimi, Jasmin
Gelpi, Ellen
Aldecoa, Iban
Ricken, Gerda
Danics, Krisztina
Keller, Eva
Kovacs, Gabor G.
Accumulation of prion protein in the vagus nerve in creutzfeldt–jakob disease
title Accumulation of prion protein in the vagus nerve in creutzfeldt–jakob disease
title_full Accumulation of prion protein in the vagus nerve in creutzfeldt–jakob disease
title_fullStr Accumulation of prion protein in the vagus nerve in creutzfeldt–jakob disease
title_full_unstemmed Accumulation of prion protein in the vagus nerve in creutzfeldt–jakob disease
title_short Accumulation of prion protein in the vagus nerve in creutzfeldt–jakob disease
title_sort accumulation of prion protein in the vagus nerve in creutzfeldt–jakob disease
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593447/
https://www.ncbi.nlm.nih.gov/pubmed/30801763
http://dx.doi.org/10.1002/ana.25451
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