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Helix-A peptide prevents gp120-mediated neuronal loss

AIM: The human-immunodeficiency virus (HIV) envelope protein gp120 promotes synaptic damage similar to that observed in people living with HIV who have neurocognitive disorders. The neurotoxic effect of gp120 appears to occur through the α-helix motif that binds to neuronal microtubules (MTs). In th...

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Detalles Bibliográficos
Autores principales: Avdoshina, Valeria, Taraballi, Francesca, Tasciotti, Ennio, Üren, Aykut, Mocchetti, Italo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593494/
https://www.ncbi.nlm.nih.gov/pubmed/31238994
http://dx.doi.org/10.1186/s13041-019-0482-z