Mucosal delivery of Lactococcus lactis carrying an anti-TNF scFv expression vector ameliorates experimental colitis in mice

BACKGROUND: Anti-Tumor Necrosis Factor-alpha therapy has become clinically important for treating inflammatory bowel disease. However, the use of conventional immunotherapy requires a systemic exposure of patients and collateral side effects. Lactic acid bacteria have been shown to be effective as m...

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Detalles Bibliográficos
Autores principales: Chiabai, Maria José, Almeida, Juliana Franco, de Azevedo, Mariana Gabriela Dantas, Fernandes, Suelen Soares, Pereira, Vanessa Bastos, de Castro, Raffael Júnio Araújo, Jerônimo, Márcio Sousa, Sousa, Isabel Garcia, de Souza Vianna, Leonora Maciel, Miyoshi, Anderson, Bocca, Anamelia Lorenzetti, Maranhão, Andrea Queiroz, Brigido, Marcelo Macedo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593574/
https://www.ncbi.nlm.nih.gov/pubmed/31238939
http://dx.doi.org/10.1186/s12896-019-0518-6

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