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Neoantigens in Chronic Obstructive Pulmonary Disease and Lung Cancer: A Point of View
The goal of this manuscript is to explore the role of clinical proteomics for detecting mutations in chronic obstructive pulmonary disease (COPD) and lung cancer by mass spectrometry‐based technology. COPD and lung cancer caused by smoke inhalation are most likely linked by challenging the immune sy...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593722/ https://www.ncbi.nlm.nih.gov/pubmed/30706659 http://dx.doi.org/10.1002/prca.201800093 |
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author | Zeneyedpour, Lona Dekker, Lennard J. M. van Sten‐van`t Hoff, Jenny J. M. Burgers, Peter C. ten Hacken, Nick H. T. Luider, Theo M. |
author_facet | Zeneyedpour, Lona Dekker, Lennard J. M. van Sten‐van`t Hoff, Jenny J. M. Burgers, Peter C. ten Hacken, Nick H. T. Luider, Theo M. |
author_sort | Zeneyedpour, Lona |
collection | PubMed |
description | The goal of this manuscript is to explore the role of clinical proteomics for detecting mutations in chronic obstructive pulmonary disease (COPD) and lung cancer by mass spectrometry‐based technology. COPD and lung cancer caused by smoke inhalation are most likely linked by challenging the immune system via partly shared pathways. Genome‐wide association studies have identified several single nucleotide polymorphisms which predispose an increased susceptibility to COPD and lung cancer. In lung cancer, this leads to coding mutations in the affected tissues, development of neoantigens, and different functionality and abundance of proteins in specific pathways. If a similar reasoning can also be applied in COPD will be discussed. The technology of mass spectrometry has developed into an advanced technology for proteome research detecting mutated peptides or proteins and finding relevant molecular mechanisms that will enable predicting the response to immunotherapy in COPD and lung cancer patients. |
format | Online Article Text |
id | pubmed-6593722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65937222019-07-10 Neoantigens in Chronic Obstructive Pulmonary Disease and Lung Cancer: A Point of View Zeneyedpour, Lona Dekker, Lennard J. M. van Sten‐van`t Hoff, Jenny J. M. Burgers, Peter C. ten Hacken, Nick H. T. Luider, Theo M. Proteomics Clin Appl Viewpoint The goal of this manuscript is to explore the role of clinical proteomics for detecting mutations in chronic obstructive pulmonary disease (COPD) and lung cancer by mass spectrometry‐based technology. COPD and lung cancer caused by smoke inhalation are most likely linked by challenging the immune system via partly shared pathways. Genome‐wide association studies have identified several single nucleotide polymorphisms which predispose an increased susceptibility to COPD and lung cancer. In lung cancer, this leads to coding mutations in the affected tissues, development of neoantigens, and different functionality and abundance of proteins in specific pathways. If a similar reasoning can also be applied in COPD will be discussed. The technology of mass spectrometry has developed into an advanced technology for proteome research detecting mutated peptides or proteins and finding relevant molecular mechanisms that will enable predicting the response to immunotherapy in COPD and lung cancer patients. John Wiley and Sons Inc. 2019-02-11 2019-03 /pmc/articles/PMC6593722/ /pubmed/30706659 http://dx.doi.org/10.1002/prca.201800093 Text en © 2019 The Authors. Proteomics – Clinical Application published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Viewpoint Zeneyedpour, Lona Dekker, Lennard J. M. van Sten‐van`t Hoff, Jenny J. M. Burgers, Peter C. ten Hacken, Nick H. T. Luider, Theo M. Neoantigens in Chronic Obstructive Pulmonary Disease and Lung Cancer: A Point of View |
title | Neoantigens in Chronic Obstructive Pulmonary Disease and Lung Cancer: A Point of View |
title_full | Neoantigens in Chronic Obstructive Pulmonary Disease and Lung Cancer: A Point of View |
title_fullStr | Neoantigens in Chronic Obstructive Pulmonary Disease and Lung Cancer: A Point of View |
title_full_unstemmed | Neoantigens in Chronic Obstructive Pulmonary Disease and Lung Cancer: A Point of View |
title_short | Neoantigens in Chronic Obstructive Pulmonary Disease and Lung Cancer: A Point of View |
title_sort | neoantigens in chronic obstructive pulmonary disease and lung cancer: a point of view |
topic | Viewpoint |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593722/ https://www.ncbi.nlm.nih.gov/pubmed/30706659 http://dx.doi.org/10.1002/prca.201800093 |
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