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Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange
A general approach for the efficient hydrogen‐isotope exchange of nucleobase derivatives is described. Catalyzed by ruthenium nanoparticles, using mild reaction conditions, and involving either D(2) or T(2) as isotopic sources, this reaction possesses a wide substrate scope and a high solvent tolera...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593778/ https://www.ncbi.nlm.nih.gov/pubmed/30768844 http://dx.doi.org/10.1002/anie.201813946 |
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author | Palazzolo, Alberto Feuillastre, Sophie Pfeifer, Viktor Garcia‐Argote, Sébastien Bouzouita, Donia Tricard, Simon Chollet, Céline Marcon, Elodie Buisson, David‐Alexandre Cholet, Sophie Fenaille, François Lippens, Guy Chaudret, Bruno Pieters, Grégory |
author_facet | Palazzolo, Alberto Feuillastre, Sophie Pfeifer, Viktor Garcia‐Argote, Sébastien Bouzouita, Donia Tricard, Simon Chollet, Céline Marcon, Elodie Buisson, David‐Alexandre Cholet, Sophie Fenaille, François Lippens, Guy Chaudret, Bruno Pieters, Grégory |
author_sort | Palazzolo, Alberto |
collection | PubMed |
description | A general approach for the efficient hydrogen‐isotope exchange of nucleobase derivatives is described. Catalyzed by ruthenium nanoparticles, using mild reaction conditions, and involving either D(2) or T(2) as isotopic sources, this reaction possesses a wide substrate scope and a high solvent tolerability. This novel method facilitates the access to essential diagnostic tools in drug discovery and development: tritiated pharmaceuticals with high specific activities and deuterated oligonucleotides suitable for use as internal standards during LC‐MS quantification. |
format | Online Article Text |
id | pubmed-6593778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65937782019-07-10 Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange Palazzolo, Alberto Feuillastre, Sophie Pfeifer, Viktor Garcia‐Argote, Sébastien Bouzouita, Donia Tricard, Simon Chollet, Céline Marcon, Elodie Buisson, David‐Alexandre Cholet, Sophie Fenaille, François Lippens, Guy Chaudret, Bruno Pieters, Grégory Angew Chem Int Ed Engl Communications A general approach for the efficient hydrogen‐isotope exchange of nucleobase derivatives is described. Catalyzed by ruthenium nanoparticles, using mild reaction conditions, and involving either D(2) or T(2) as isotopic sources, this reaction possesses a wide substrate scope and a high solvent tolerability. This novel method facilitates the access to essential diagnostic tools in drug discovery and development: tritiated pharmaceuticals with high specific activities and deuterated oligonucleotides suitable for use as internal standards during LC‐MS quantification. John Wiley and Sons Inc. 2019-03-06 2019-04-01 /pmc/articles/PMC6593778/ /pubmed/30768844 http://dx.doi.org/10.1002/anie.201813946 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Communications Palazzolo, Alberto Feuillastre, Sophie Pfeifer, Viktor Garcia‐Argote, Sébastien Bouzouita, Donia Tricard, Simon Chollet, Céline Marcon, Elodie Buisson, David‐Alexandre Cholet, Sophie Fenaille, François Lippens, Guy Chaudret, Bruno Pieters, Grégory Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange |
title | Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange |
title_full | Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange |
title_fullStr | Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange |
title_full_unstemmed | Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange |
title_short | Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange |
title_sort | efficient access to deuterated and tritiated nucleobase pharmaceuticals and oligonucleotides using hydrogen‐isotope exchange |
topic | Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593778/ https://www.ncbi.nlm.nih.gov/pubmed/30768844 http://dx.doi.org/10.1002/anie.201813946 |
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