Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen‐Isotope Exchange

A general approach for the efficient hydrogen‐isotope exchange of nucleobase derivatives is described. Catalyzed by ruthenium nanoparticles, using mild reaction conditions, and involving either D(2) or T(2) as isotopic sources, this reaction possesses a wide substrate scope and a high solvent tolera...

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Detalles Bibliográficos
Autores principales: Palazzolo, Alberto, Feuillastre, Sophie, Pfeifer, Viktor, Garcia‐Argote, Sébastien, Bouzouita, Donia, Tricard, Simon, Chollet, Céline, Marcon, Elodie, Buisson, David‐Alexandre, Cholet, Sophie, Fenaille, François, Lippens, Guy, Chaudret, Bruno, Pieters, Grégory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593778/
https://www.ncbi.nlm.nih.gov/pubmed/30768844
http://dx.doi.org/10.1002/anie.201813946

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