Limb specific Acvr1‐knockout during embryogenesis in mice exhibits great toe malformation as seen in Fibrodysplasia Ossificans Progressiva (FOP)

PURPOSE: This study analyzes Prx1‐specific conditional knockout of Acvr1 aiming to elucidate the endogenous role of Acvr1 during limb formation in early embryonic development. ACVR1 can exhibit activating and inhibiting function in BMP signaling. ACVR1 gain‐of‐function mutations can cause the rare d...

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Detalles Bibliográficos
Autores principales: Hildebrand, Laura, Schmidt‐von Kegler, Mareen, Walther, Maria, Seemann, Petra, Stange, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Patterns & Phenotypes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593811/
https://www.ncbi.nlm.nih.gov/pubmed/30854720
http://dx.doi.org/10.1002/dvdy.24

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