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The minimum clinically important difference: which direction to take
Over the past decades in modern medicine, there has been a shift from statistical significance to clinical relevance when it comes to interpreting results from clinical trials. A concept that is increasingly being used as a surrogate for clinical relevance and effect size calculation is the minimum...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593833/ https://www.ncbi.nlm.nih.gov/pubmed/30793428 http://dx.doi.org/10.1111/ene.13941 |
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| author | Draak, T. H. P. de Greef, B. T. A. Faber, C. G. Merkies, I. S. J. |
| author_facet | Draak, T. H. P. de Greef, B. T. A. Faber, C. G. Merkies, I. S. J. |
| author_sort | Draak, T. H. P. |
| collection | PubMed |
| description | Over the past decades in modern medicine, there has been a shift from statistical significance to clinical relevance when it comes to interpreting results from clinical trials. A concept that is increasingly being used as a surrogate for clinical relevance and effect size calculation is the minimum clinically important difference (MCID). In this paper, an overview is presented of the most important aspects of the MCID concept used in research trials and a discussion of what this means for the neurological patient in clinical trials and daily practice is given. Is the MCID the best outcome measure cut‐off to be implemented? |
| format | Online Article Text |
| id | pubmed-6593833 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-65938332019-07-10 The minimum clinically important difference: which direction to take Draak, T. H. P. de Greef, B. T. A. Faber, C. G. Merkies, I. S. J. Eur J Neurol Review Article Over the past decades in modern medicine, there has been a shift from statistical significance to clinical relevance when it comes to interpreting results from clinical trials. A concept that is increasingly being used as a surrogate for clinical relevance and effect size calculation is the minimum clinically important difference (MCID). In this paper, an overview is presented of the most important aspects of the MCID concept used in research trials and a discussion of what this means for the neurological patient in clinical trials and daily practice is given. Is the MCID the best outcome measure cut‐off to be implemented? John Wiley and Sons Inc. 2019-03-25 2019-06 /pmc/articles/PMC6593833/ /pubmed/30793428 http://dx.doi.org/10.1111/ene.13941 Text en © 2019 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Review Article Draak, T. H. P. de Greef, B. T. A. Faber, C. G. Merkies, I. S. J. The minimum clinically important difference: which direction to take |
| title | The minimum clinically important difference: which direction to take |
| title_full | The minimum clinically important difference: which direction to take |
| title_fullStr | The minimum clinically important difference: which direction to take |
| title_full_unstemmed | The minimum clinically important difference: which direction to take |
| title_short | The minimum clinically important difference: which direction to take |
| title_sort | minimum clinically important difference: which direction to take |
| topic | Review Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593833/ https://www.ncbi.nlm.nih.gov/pubmed/30793428 http://dx.doi.org/10.1111/ene.13941 |
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